Facilitation of cocaine kindling by glucocorticoids in rats

Mitchel A. Kling; Mark A. Smith; John R. Glowa; Daniel Pluznik; Jay Demas; Michael D. DeBellis; Philip W. Gold; Jay Schulkin

doi:10.1016/0006-8993(93)90497-B

Facilitation of cocaine kindling by glucocorticoids in rats

Mitchel A. Kling, Mark A. Smith, John R. Glowa, Daniel Pluznik, Jay Demas, Michael D. DeBellis, Philip W. Gold, Jay Schulkin

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with which they show a close functional relationship. These results may be of interest in the light of data showing that glucocorticoids increase CRH expression in the central nucleus of the amygdala, which is an important site for the development of kindling.

Original language	English (US)
Pages (from-to)	163-166
Number of pages	4
Journal	Brain Research
Volume	629
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)90497-B
State	Published - Nov 26 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90497-B

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title = "Facilitation of cocaine kindling by glucocorticoids in rats",

abstract = "We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with which they show a close functional relationship. These results may be of interest in the light of data showing that glucocorticoids increase CRH expression in the central nucleus of the amygdala, which is an important site for the development of kindling.",

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AU - Smith, Mark A.

AU - Glowa, John R.

AU - Pluznik, Daniel

AU - Demas, Jay

AU - DeBellis, Michael D.

AU - Gold, Philip W.

AU - Schulkin, Jay

PY - 1993/11/26

Y1 - 1993/11/26

N2 - We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with which they show a close functional relationship. These results may be of interest in the light of data showing that glucocorticoids increase CRH expression in the central nucleus of the amygdala, which is an important site for the development of kindling.

AB - We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with which they show a close functional relationship. These results may be of interest in the light of data showing that glucocorticoids increase CRH expression in the central nucleus of the amygdala, which is an important site for the development of kindling.

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JF - Brain Research

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ER -

Facilitation of cocaine kindling by glucocorticoids in rats

Abstract

All Science Journal Classification (ASJC) codes

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