Fabrication, biodegradation behavior and cytotoxicity of Mg-nanodiamond composites for implant application

Haibo Gong, Babak Anasori, Chris R. Dennison, Kun Wang, E. Caglan Kumbur, Randy Strich, Jack G. Zhou

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Mg-based biodegradable implants offer several advantages over their non-degradable or degradable polymeric counterparts used today. However, the low corrosion resistance of Mg in physiologic environment remained as concerns. In this research, nanodiamond (ND) was uniformly dispersed in Mg matrix to induce a protective layer on Mg surface during corrosion. Compared with pure Mg, fabricated Mg-ND nanocomposites had lower corrosion rates, higher corrosion potential, and higher corrosion resistance. Specifically, the corrosion rate of Mg was reduced by 4.5 times by adding 5 wt% of ND particles. Corrosion inhibition effect of ND was thus validated. The chemical interaction and physical adsorption of the ions from simulated body fluid on ND might be the main reason for enhanced corrosion resistance. In vitro biocompatibility test results indicated that Mg-ND nanocomposites were biocompatible since cells growing in contact with corrosion products of Mg-ND maintained high cell viability and healthy morphology. Therefore, Mg-ND nanocomposites with homogenous ND dispersion, enhanced corrosion resistance, and good biocompatibility might be an excellent candidate material for biodegradable implant application.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Materials Science: Materials in Medicine
Volume26
Issue number2
DOIs
StatePublished - Feb 2015

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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