Exercise-induced rhabdomyolysis mechanisms and prevention: A literature review

Jooyoung Kim, Joohyung Lee, Sojung Kim, Ho Young Ryu, Kwang Suk Cha, Dong Jun Sung

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Exercise-induced rhabdomyolysis (exRML), a pathophysiological condition of skeletal muscle cell damage that may cause acute renal failure and in some cases death. Increased Ca2+ level in cells along with functional degradation of cell signaling system and cell matrix have been suggested as the major pathological mechanisms associated with exRML. The onset of exRML may be exhibited in athletes as well as in general population. Previous studies have reported that possible causes of exRML were associated with excessive eccentric contractions in high temperature, abnormal electrolytes balance, and nutritional deficiencies possible genetic defects. However, the underlying mechanisms of exRML have not been clearly established among health professionals or sports medicine personnel. Therefore, we reviewed the possible mechanisms and correlated prevention of exRML, while providing useful and practical information for the athlete and general exercising population.

Original languageEnglish (US)
Pages (from-to)324-333
Number of pages10
JournalJournal of Sport and Health Science
Issue number3
StatePublished - Sep 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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