@article{f140860f2acf478092b70a5953a22aa4,
title = "Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative",
abstract = "Glycyrrhetinic acid exhibits many pharmacological activities, including the ability to block gap junctional communication. However, the mechanism of glycyrrhetinic action is not clear. Others have shown that glycyrrhetinic acid apparently binds to a single proteinatious binding site in the plasma membrane. We present evidence that while exposure to glycyrrhetinic acid derivatives may not affect protein synthesis or location, it does seem to alter connexon particle packing in gap junction plaques.",
author = "Goldberg, {Gary S.} and Moreno, {Alonso P.} and Bechberger, {John F.} and Hearn, {Stephen S.} and Shivers, {Richard R.} and Macphee, {Daniel J.} and Zhang, {Yu Chun} and Naus, {Christian C.G.}",
note = "Funding Information: We thank Miss Baxendale of Biorex Laboratories, En{\textregistered}eld, Great Britain, for 18α-carbenoxolone and B. Nicholson (SUNY, Buffalo) for gifts of cells. The work reported in this paper was undertaken during the tenure of a Research Training Fellowship awarded by the International Agency for Research on Cancer (R.2216) to G.S.G., a Grant in Aid from the American Heart Association to A.P.M., and a grant from the Medical Research Council of Canada to C.C.G.N.",
year = "1996",
month = jan,
day = "10",
doi = "10.1006/excr.1996.0006",
language = "English (US)",
volume = "222",
pages = "48--53",
journal = "Experimental Cell Research",
issn = "0014-4827",
publisher = "Elsevier Inc.",
number = "1",
}