TY - JOUR
T1 - Everyday action impairment in Parkinson's disease dementia
AU - Giovannetti, Tania
AU - Britnell, Priscilla
AU - Brennan, Laura
AU - Siderowf, Andrew
AU - Grossman, Murray
AU - Libon, David J.
AU - Bettcher, Brianne M.
AU - Rouzard, Francesca
AU - Eppig, Joel
AU - Seidel, Gregory A.
PY - 2012/9
Y1 - 2012/9
N2 - This study examined everyday action impairment in participants with Parkinson's disease dementia (PDD) by comparison with participants with Parkinson's disease-no dementia (PD) or Alzheimer's disease (AD) and in reference to a neuropsychological model. Participants with PDD (n = 20), PD (n = 20), or AD (n = 20) were administered performance-based measures of everyday functioning that allowed for the quantification of overall performance and error types. Also, caregiver ratings of functional independence were obtained. On performance-based tests, the PDD group exhibited greater functional impairment than the PD group but comparable overall impairment relative to the AD group. Error patterns did not differ between PDD and PD participants but the PDD group demonstrated a higher proportion of commission errors and lower proportion of omission errors relative to the AD group. Hierarchical regression analyses showed omission errors were significantly predicted by neuropsychological measures of episodic memory, whereas commission errors were predicted by both measures of general dementia severity (MMSE) and executive control. Everyday action impairment in PDD differs quantitatively from PD but qualitatively from AD and may be characterized by a relatively high proportion of commission errors'an error type associated with executive control deficits.
AB - This study examined everyday action impairment in participants with Parkinson's disease dementia (PDD) by comparison with participants with Parkinson's disease-no dementia (PD) or Alzheimer's disease (AD) and in reference to a neuropsychological model. Participants with PDD (n = 20), PD (n = 20), or AD (n = 20) were administered performance-based measures of everyday functioning that allowed for the quantification of overall performance and error types. Also, caregiver ratings of functional independence were obtained. On performance-based tests, the PDD group exhibited greater functional impairment than the PD group but comparable overall impairment relative to the AD group. Error patterns did not differ between PDD and PD participants but the PDD group demonstrated a higher proportion of commission errors and lower proportion of omission errors relative to the AD group. Hierarchical regression analyses showed omission errors were significantly predicted by neuropsychological measures of episodic memory, whereas commission errors were predicted by both measures of general dementia severity (MMSE) and executive control. Everyday action impairment in PDD differs quantitatively from PD but qualitatively from AD and may be characterized by a relatively high proportion of commission errors'an error type associated with executive control deficits.
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U2 - 10.1017/S135561771200046X
DO - 10.1017/S135561771200046X
M3 - Article
C2 - 22621995
AN - SCOPUS:84865991335
SN - 1355-6177
VL - 18
SP - 787
EP - 798
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 5
ER -