Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation

Michael F. Henry; John E. Cronan

doi:10.1016/0022-2836(91)90574-P

Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation

Michael F. Henry
, John E. Cronan

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible β-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.

Original language	English (US)
Pages (from-to)	843-849
Number of pages	7
Journal	Journal of Molecular Biology
Volume	222
Issue number	4
DOIs	https://doi.org/10.1016/0022-2836(91)90574-P
State	Published - Dec 20 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Molecular Biology

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10.1016/0022-2836(91)90574-P

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title = "Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation",

abstract = "The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible β-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.",

author = "Henry, \{Michael F.\} and Cronan, \{John E.\}",

note = "Funding Information: We t.hank C. DiRusso and H. Bachman for the bacterial strains, J. Schwab for t,he gift of Z-3-decenoyl-NAC and J. Delia for preparing the illustrations. This work was supported by a Public Health Service research grant from the National Institutes of Health.",

year = "1991",

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doi = "10.1016/0022-2836(91)90574-P",

language = "English (US)",

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journal = "Journal of Molecular Biology",

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T1 - Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation

AU - Henry, Michael F.

AU - Cronan, John E.

N1 - Funding Information: We t.hank C. DiRusso and H. Bachman for the bacterial strains, J. Schwab for t,he gift of Z-3-decenoyl-NAC and J. Delia for preparing the illustrations. This work was supported by a Public Health Service research grant from the National Institutes of Health.

PY - 1991/12/20

Y1 - 1991/12/20

N2 - The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible β-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.

AB - The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible β-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.

UR - https://www.scopus.com/pages/publications/0026335805

UR - https://www.scopus.com/pages/publications/0026335805#tab=citedBy

U2 - 10.1016/0022-2836(91)90574-P

DO - 10.1016/0022-2836(91)90574-P

M3 - Article

C2 - 1722255

AN - SCOPUS:0026335805

SN - 0022-2836

VL - 222

SP - 843

EP - 849

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 4

ER -

Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation

Abstract

All Science Journal Classification (ASJC) codes

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