Erythrocytes in Hb SC disease are microcytic and hyperchromic

Samir K. Ballas, William Kocher

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We have used the new Technicon H.1 Hematology Analyzer to determine the indices of erythrocytes obtained from 18 nonthalassemic (αα/αα genotype) adult patients with Hb SC disease. Controls were 14 normal black adults and 29 white adults. The data showed that SC erythrocytes are significantly smaller than normal RBC (P < .001) with a significantly higher MCHC value (P < .001) than controls. These features of SC RBC could not be reproduced by an Ortho ELT‐8 electonic counter. Hb SC erythrocytes have unique indices which are best demonstrated either by semimanual methods or by the H.1 system.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalAmerican Journal of Hematology
Issue number1
StatePublished - May 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology


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