Entry of herpesviruses into mammalian cells

E. E. Heldwein, C. Krummenacher

Research output: Contribution to journalReview articlepeer-review

287 Scopus citations


The mechanism that herpesviruses use to enter cells is one of the most complex viral entry mechanisms studied so far. This complexity seems to mount as new participants, both cellular receptors and viral glycoproteins, are identified. Recent structural work on entry glycoproteins gD and gB from herpes simplex virus (HSV) 1 has illuminated the functional roles of these glycoproteins in the process of entry. In doing so, it provided information on the mechanism of two critical steps of HSV entry: receptor-mediated activation and membrane fusion. Remarkably, it is becoming clear that herpesviruses have a lot in common with other, simpler viruses.

Original languageEnglish (US)
Pages (from-to)1653-1668
Number of pages16
JournalCellular and Molecular Life Sciences
Issue number11
StatePublished - Jun 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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