Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by nectin-1/HveC

Sarah M. Richart, Scott A. Simpson, Claude Krummenacher, J. Charles Whitbeck, Lewis I. Pizer, Gary H. Cohen, Roselyn J. Eisenberg, Christine L. Wilcox

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.

Original languageEnglish (US)
Pages (from-to)3307-3311
Number of pages5
JournalJournal of virology
Volume77
Issue number5
DOIs
StatePublished - Mar 2003

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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