Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by nectin-1/HveC

Sarah M. Richart; Scott A. Simpson; Claude Krummenacher; J. Charles Whitbeck; Lewis I. Pizer; Gary H. Cohen; Roselyn J. Eisenberg; Christine L. Wilcox

doi:10.1128/JVI.77.5.3307-3311.2003

Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by nectin-1/HveC

Sarah M. Richart, Scott A. Simpson, Claude Krummenacher, J. Charles Whitbeck, Lewis I. Pizer, Gary H. Cohen, Roselyn J. Eisenberg, Christine L. Wilcox

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.

Original language	English (US)
Pages (from-to)	3307-3311
Number of pages	5
Journal	Journal of virology
Volume	77
Issue number	5
DOIs	https://doi.org/10.1128/JVI.77.5.3307-3311.2003
State	Published - Mar 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.77.5.3307-3311.2003

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title = "Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by nectin-1/HveC",

abstract = "Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.",

author = "Richart, {Sarah M.} and Simpson, {Scott A.} and Claude Krummenacher and Whitbeck, {J. Charles} and Pizer, {Lewis I.} and Cohen, {Gary H.} and Eisenberg, {Roselyn J.} and Wilcox, {Christine L.}",

year = "2003",

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AU - Richart, Sarah M.

AU - Simpson, Scott A.

AU - Krummenacher, Claude

AU - Whitbeck, J. Charles

AU - Pizer, Lewis I.

AU - Cohen, Gary H.

AU - Eisenberg, Roselyn J.

AU - Wilcox, Christine L.

PY - 2003/3

Y1 - 2003/3

N2 - Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.

AB - Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.

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ER -

Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by nectin-1/HveC

Abstract

All Science Journal Classification (ASJC) codes

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