TY - JOUR
T1 - Enhanced tumor response to cycle-specific chemotherapy by pulse total parenteral nutrition
AU - Torosian, Michael H.
AU - Mullen, James L.
AU - Stein, T. Peter
AU - Miller, Elizabeth E.
AU - Zinsser, Kendall R.
AU - Buzby, Gordon P.
N1 - Funding Information:
’ This research was supported in part by educational grants from McGaw Laboratories (Irvine, Calif.), Veterans Administration Medical Research Funds, the McCabe Fund, American Cancer Society Institution Research Grant IN-135C, and National Institutes of Health Grant CA-18575. Presented at the annual meeting of the Association for Academic Surgery, San Diego, Calif., November 7-10, 1982. * To whom reprint requests should be addressed at: Department of Surgery, 4th Floor, Silverstein Pavilion, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pa. 191 04.
PY - 1985/8
Y1 - 1985/8
N2 - Exogenous nutrient administration has been shown to significantly stimulate tumor growth in numerous animal models. The present study was performed to determine if substrate-induced alterations in tumor metabolism could be exploited to potentiate tumor response to cycle-specific chemotherapy. Following subcutaneous mammary tumor (AC-33) implantation, 55 female Lewis/Wistar rats were randomly assigned to one of three nutritional regimens for 48 hr: (1) protein-depleted chow (0.03% protein) ad lib per os, (2) standard rat chow (22.0% protein) ad lib per os, or (3) total parenteral nutrition (TPN; 18.6% dextrose/2.8% amino acids). One-half of the animals in each group received a single dose of methotrexate (5 mg/kg im) while the remaining animals received placebo (saline) injections. At sacrifice, methotrexate-treated animals receiving TPN demonstrated a significantly smaller tumor volume (0.47 ± 0.44 cm3) compared to animals given either protein depleted chow (1.30 ± 0.76 cm3) or standard rat chow (1.34 ± 0.83 cm3) (P < 0.01). In this animal model, adjuvant TPN was found to significantly potentiate tumor response to cycle-specific chemotherapy with no detectable exacerbation of host toxicity.
AB - Exogenous nutrient administration has been shown to significantly stimulate tumor growth in numerous animal models. The present study was performed to determine if substrate-induced alterations in tumor metabolism could be exploited to potentiate tumor response to cycle-specific chemotherapy. Following subcutaneous mammary tumor (AC-33) implantation, 55 female Lewis/Wistar rats were randomly assigned to one of three nutritional regimens for 48 hr: (1) protein-depleted chow (0.03% protein) ad lib per os, (2) standard rat chow (22.0% protein) ad lib per os, or (3) total parenteral nutrition (TPN; 18.6% dextrose/2.8% amino acids). One-half of the animals in each group received a single dose of methotrexate (5 mg/kg im) while the remaining animals received placebo (saline) injections. At sacrifice, methotrexate-treated animals receiving TPN demonstrated a significantly smaller tumor volume (0.47 ± 0.44 cm3) compared to animals given either protein depleted chow (1.30 ± 0.76 cm3) or standard rat chow (1.34 ± 0.83 cm3) (P < 0.01). In this animal model, adjuvant TPN was found to significantly potentiate tumor response to cycle-specific chemotherapy with no detectable exacerbation of host toxicity.
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U2 - 10.1016/0022-4804(85)90167-2
DO - 10.1016/0022-4804(85)90167-2
M3 - Article
C2 - 3927061
AN - SCOPUS:0022379128
SN - 0022-4804
VL - 39
SP - 103
EP - 113
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 2
ER -