Enhanced forebrain nitric oxide synthase activity in epileptic fowl

Lakshman Sandirasegarane; John R. Mikler; John M. Tuchek; Prakash Sulakhe V

doi:10.1016/0006-8993(96)00595-1

Enhanced forebrain nitric oxide synthase activity in epileptic fowl

Lakshman Sandirasegarane, John R. Mikler, John M. Tuchek, Prakash Sulakhe V

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was ~2-fold higher in only the forebrain regions of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant increase in NOS was also evident in forebrains of 1-day-old epileptic chicks. Ca²⁺-dependency experiments confirmed that these increments were principally due to type I NOS (NOS-I). Induction of convulsions by intermittent photic stimulation did not affect pre-existing forebrain NOS-I activity. The present data suggest that an enhanced NO signaling may ensue in selected regions of the brain as an adaptive response to hereditary epileptogenesis.

Original language	English (US)
Pages (from-to)	311-313
Number of pages	3
Journal	Brain Research
Volume	735
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(96)00595-1
State	Published - Oct 7 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(96)00595-1

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title = "Enhanced forebrain nitric oxide synthase activity in epileptic fowl",

abstract = "Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was ~2-fold higher in only the forebrain regions of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant increase in NOS was also evident in forebrains of 1-day-old epileptic chicks. Ca2+-dependency experiments confirmed that these increments were principally due to type I NOS (NOS-I). Induction of convulsions by intermittent photic stimulation did not affect pre-existing forebrain NOS-I activity. The present data suggest that an enhanced NO signaling may ensue in selected regions of the brain as an adaptive response to hereditary epileptogenesis.",

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AU - Sandirasegarane, Lakshman

AU - Mikler, John R.

AU - Tuchek, John M.

AU - Sulakhe V, Prakash

PY - 1996/10/7

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N2 - Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was ~2-fold higher in only the forebrain regions of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant increase in NOS was also evident in forebrains of 1-day-old epileptic chicks. Ca2+-dependency experiments confirmed that these increments were principally due to type I NOS (NOS-I). Induction of convulsions by intermittent photic stimulation did not affect pre-existing forebrain NOS-I activity. The present data suggest that an enhanced NO signaling may ensue in selected regions of the brain as an adaptive response to hereditary epileptogenesis.

AB - Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was ~2-fold higher in only the forebrain regions of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant increase in NOS was also evident in forebrains of 1-day-old epileptic chicks. Ca2+-dependency experiments confirmed that these increments were principally due to type I NOS (NOS-I). Induction of convulsions by intermittent photic stimulation did not affect pre-existing forebrain NOS-I activity. The present data suggest that an enhanced NO signaling may ensue in selected regions of the brain as an adaptive response to hereditary epileptogenesis.

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Enhanced forebrain nitric oxide synthase activity in epileptic fowl

Abstract

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