Electrochemical redundant microsensor arrays for glucose monitoring with patterned polymer films

Amos Mugweru, Becky L. Clark, Michael V. Pishko

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Redundant microsensor arrays for glucose sensing were fabricated using photopolymerization of poly(ethylene glycol) diacrylate (PEG-DA) with 2-hydroxy-2-methyl phenyl-propanone as photoinitiator to encapsulate the enzyme glucose oxidase. Silicon micro fabrication technologies were used to fabricate microelectrode sensor arrays on flexible polyimide sheets. These microarray sensors were individually addressable as observed using square-wave voltammetry. Redox polymer, poly[4-vinylpyridine Os(bipyridine)2Cl]-co- ethylamine, was first immobilized on the electrode surface and then glucose oxidase was entrapped in PEG-DA hydrogels. The redox polymer was found to exchange electrons with glucose oxidase in biocompatible PEG-DA hydrogels. The entrapped glucose oxidase was found to respond linearly to glucose in solution (0-20 mM) as determined using square-wave voltammetry.

Original languageEnglish (US)
Pages (from-to)453-458
Number of pages6
JournalElectroanalysis
Volume19
Issue number4
DOIs
Publication statusPublished - Feb 1 2007

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Electrochemistry

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