Abstract
Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-174 |
| Number of pages | 10 |
| Journal | Journal of Electrochemical Science and Engineering |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 6 2019 |
All Science Journal Classification (ASJC) codes
- Chemical Engineering (miscellaneous)
- Colloid and Surface Chemistry
- Materials Chemistry
- Electrochemistry