Electrochemical method for analysis of cholesterol based on in situ synthesized graphene decorated with zinc oxide nanoparticles

Elli Watanabe; Ryan Spidle; Steven Caudle; Geoffrey Manani; Adam K. Wanekaya; Amos Mugweru

doi:10.1149/2.001401ssl

Electrochemical method for analysis of cholesterol based on in situ synthesized graphene decorated with zinc oxide nanoparticles

Elli Watanabe, Ryan Spidle, Steven Caudle, Geoffrey Manani, Adam K. Wanekaya, Amos Mugweru

Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Graphene decorated with zinc oxide nanoparticles were synthesized in a single step. Through this process zinc oxide nanoparticles were deposited onto graphene nanosheets. The nano-composites were characterized usingX- rayDiffraction (XRD),Scanning Electron Microscope (SEM), energy dispersive spectroscopy (EDX), cyclic voltammetry and electrochemical impedance spectroscopy. The nanocomposite material displayed excellent catalytic properties toward Cholesterol in combination with cholesterol oxidase (ChOx). The cholesterol detection limit was found to be 5.0 μmol L^-1 and a sensitivity 1.3 μA/μM cm² with linear correlation coefficient R² = 0.980. The Cholesterol oxidation also followed the Michaelis-Menten kinetics with apparent Km of 46.5 μM.

Original language	English (US)
Pages (from-to)	M5-M9
Journal	ECS Solid State Letters
Volume	3
Issue number	1
DOIs	https://doi.org/10.1149/2.001401ssl
State	Published - 2014

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

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title = "Electrochemical method for analysis of cholesterol based on in situ synthesized graphene decorated with zinc oxide nanoparticles",

abstract = "Graphene decorated with zinc oxide nanoparticles were synthesized in a single step. Through this process zinc oxide nanoparticles were deposited onto graphene nanosheets. The nano-composites were characterized usingX- rayDiffraction (XRD),Scanning Electron Microscope (SEM), energy dispersive spectroscopy (EDX), cyclic voltammetry and electrochemical impedance spectroscopy. The nanocomposite material displayed excellent catalytic properties toward Cholesterol in combination with cholesterol oxidase (ChOx). The cholesterol detection limit was found to be 5.0 μmol L-1 and a sensitivity 1.3 μA/μM cm2 with linear correlation coefficient R2 = 0.980. The Cholesterol oxidation also followed the Michaelis-Menten kinetics with apparent Km of 46.5 μM.",

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T1 - Electrochemical method for analysis of cholesterol based on in situ synthesized graphene decorated with zinc oxide nanoparticles

AU - Watanabe, Elli

AU - Spidle, Ryan

AU - Caudle, Steven

AU - Manani, Geoffrey

AU - Wanekaya, Adam K.

AU - Mugweru, Amos

PY - 2014

Y1 - 2014

N2 - Graphene decorated with zinc oxide nanoparticles were synthesized in a single step. Through this process zinc oxide nanoparticles were deposited onto graphene nanosheets. The nano-composites were characterized usingX- rayDiffraction (XRD),Scanning Electron Microscope (SEM), energy dispersive spectroscopy (EDX), cyclic voltammetry and electrochemical impedance spectroscopy. The nanocomposite material displayed excellent catalytic properties toward Cholesterol in combination with cholesterol oxidase (ChOx). The cholesterol detection limit was found to be 5.0 μmol L-1 and a sensitivity 1.3 μA/μM cm2 with linear correlation coefficient R2 = 0.980. The Cholesterol oxidation also followed the Michaelis-Menten kinetics with apparent Km of 46.5 μM.

AB - Graphene decorated with zinc oxide nanoparticles were synthesized in a single step. Through this process zinc oxide nanoparticles were deposited onto graphene nanosheets. The nano-composites were characterized usingX- rayDiffraction (XRD),Scanning Electron Microscope (SEM), energy dispersive spectroscopy (EDX), cyclic voltammetry and electrochemical impedance spectroscopy. The nanocomposite material displayed excellent catalytic properties toward Cholesterol in combination with cholesterol oxidase (ChOx). The cholesterol detection limit was found to be 5.0 μmol L-1 and a sensitivity 1.3 μA/μM cm2 with linear correlation coefficient R2 = 0.980. The Cholesterol oxidation also followed the Michaelis-Menten kinetics with apparent Km of 46.5 μM.

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Electrochemical method for analysis of cholesterol based on in situ synthesized graphene decorated with zinc oxide nanoparticles

Abstract

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