Electrochemical and Spectroscopic Characteristics of Artemisinin Antimalarial Drug: Charge Transfer Redox Process

Amos M. Mugweru; Andrew Shore; Helen K. Kahi; Geoffrey N. Kamau

doi:10.1002/kin.20971

Electrochemical and Spectroscopic Characteristics of Artemisinin Antimalarial Drug: Charge Transfer Redox Process

Amos M. Mugweru, Andrew Shore, Helen K. Kahi, Geoffrey N. Kamau

Chemistry

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6 Scopus citations

Abstract

Artemisinin is a plant extract and popular in treating many diseases including malaria. It is a sesquiterpene lactone with several binding modes to several molecules. Oxidation and reduction of this molecule at different electrode materials was studied in tetrabutyl ammonium bromide in acetonitrile solution. The apparent standard heterogeneous rate constant for electron transfer (k_h) was found to be 23 cm s⁻¹. The value of the electron transfer coefficient (αn_a) was found to be 0.496. The diffusion coefficient (D) was found to be 3.34 × 10⁻⁶ cm s⁻¹. Gold (Au), glassy carbon, and pyrolytic graphite electrodes exhibited distinguishable current densities. A value of E_1/2 = –0.81 V versus Ag/AgCl was obtained, and a value of n = 1.52 (2) was estimated.

Original language	English (US)
Pages (from-to)	72-78
Number of pages	7
Journal	International Journal of Chemical Kinetics
Volume	48
Issue number	2
DOIs	https://doi.org/10.1002/kin.20971
State	Published - Feb 1 2016

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Electrochemical and Spectroscopic Characteristics of Artemisinin Antimalarial Drug: Charge Transfer Redox Process",

abstract = "Artemisinin is a plant extract and popular in treating many diseases including malaria. It is a sesquiterpene lactone with several binding modes to several molecules. Oxidation and reduction of this molecule at different electrode materials was studied in tetrabutyl ammonium bromide in acetonitrile solution. The apparent standard heterogeneous rate constant for electron transfer (kh) was found to be 23 cm s−1. The value of the electron transfer coefficient (αna) was found to be 0.496. The diffusion coefficient (D) was found to be 3.34 × 10−6 cm s−1. Gold (Au), glassy carbon, and pyrolytic graphite electrodes exhibited distinguishable current densities. A value of E1/2 = –0.81 V versus Ag/AgCl was obtained, and a value of n = 1.52 (2) was estimated.",

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T1 - Electrochemical and Spectroscopic Characteristics of Artemisinin Antimalarial Drug

T2 - Charge Transfer Redox Process

AU - Mugweru, Amos M.

AU - Shore, Andrew

AU - Kahi, Helen K.

AU - Kamau, Geoffrey N.

PY - 2016/2/1

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AB - Artemisinin is a plant extract and popular in treating many diseases including malaria. It is a sesquiterpene lactone with several binding modes to several molecules. Oxidation and reduction of this molecule at different electrode materials was studied in tetrabutyl ammonium bromide in acetonitrile solution. The apparent standard heterogeneous rate constant for electron transfer (kh) was found to be 23 cm s−1. The value of the electron transfer coefficient (αna) was found to be 0.496. The diffusion coefficient (D) was found to be 3.34 × 10−6 cm s−1. Gold (Au), glassy carbon, and pyrolytic graphite electrodes exhibited distinguishable current densities. A value of E1/2 = –0.81 V versus Ag/AgCl was obtained, and a value of n = 1.52 (2) was estimated.

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Electrochemical and Spectroscopic Characteristics of Artemisinin Antimalarial Drug: Charge Transfer Redox Process

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