Electrochemical and Spectroscopic Characteristics of Artemisinin Antimalarial Drug: Charge Transfer Redox Process

Amos M. Mugweru, Andrew Shore, Helen K. Kahi, Geoffrey N. Kamau

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    Artemisinin is a plant extract and popular in treating many diseases including malaria. It is a sesquiterpene lactone with several binding modes to several molecules. Oxidation and reduction of this molecule at different electrode materials was studied in tetrabutyl ammonium bromide in acetonitrile solution. The apparent standard heterogeneous rate constant for electron transfer (kh) was found to be 23 cm s−1. The value of the electron transfer coefficient (αna) was found to be 0.496. The diffusion coefficient (D) was found to be 3.34 × 10−6 cm s−1. Gold (Au), glassy carbon, and pyrolytic graphite electrodes exhibited distinguishable current densities. A value of E1/2 = –0.81 V versus Ag/AgCl was obtained, and a value of n = 1.52 (2) was estimated.

    Original languageEnglish (US)
    Pages (from-to)72-78
    Number of pages7
    JournalInternational Journal of Chemical Kinetics
    Volume48
    Issue number2
    DOIs
    StatePublished - Feb 1 2016

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry

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