Effects of oxidative stress on protein translation: Implications for cardiovascular diseases

Arnab Ghosh, Natalia Shcherbik

    Research output: Contribution to journalReview articlepeer-review

    6 Scopus citations

    Abstract

    Cardiovascular diseases (CVDs) are a group of disorders that affect the heart and blood vessels. Due to their multifactorial nature and wide variation, CVDs are the leading cause of death worldwide. Understanding the molecular alterations leading to the development of heart and vessel pathologies is crucial for successfully treating and preventing CVDs. One of the causative factors of CVD etiology and progression is acute oxidative stress, a toxic condition characterized by elevated intracellular levels of reactive oxygen species (ROS). Left unabated, ROS can damage virtually any cellular component and affect essential biological processes, including protein synthesis. Defective or insufficient protein translation results in production of faulty protein products and disturbances of protein homeostasis, thus promoting pathologies. The relationships between translational dysregulation, ROS, and cardiovascular disorders will be examined in this review.

    Original languageEnglish (US)
    Article number2661
    JournalInternational Journal of Molecular Sciences
    Volume21
    Issue number8
    DOIs
    StatePublished - Apr 2 2020

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Molecular Biology
    • Spectroscopy
    • Computer Science Applications
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry

    Fingerprint

    Dive into the research topics of 'Effects of oxidative stress on protein translation: Implications for cardiovascular diseases'. Together they form a unique fingerprint.

    Cite this