TY - JOUR
T1 - Effects of ionic liquids on metalloproteins
AU - Patel, Aashka Y.
AU - Jonnalagadda, Keertana S.
AU - Paradis, Nicholas
AU - Vaden, Timothy D.
AU - Wu, Chun
AU - Caputo, Gregory A.
N1 - Funding Information:
Funding: This research was funded by the National Science Foundation, grant number DMR 1904797.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline. Therefore, there is a pressing need to understand the structure and function of proteins in novel environments with ILs. Understanding the short-term and long-term stability of protein molecules in IL formulations will be key to using ILs for protein technologies. Similarly, ILs have been investigated as part of therapeutic delivery systems and implicated in numerous studies in which ILs impact the activity and/or stability of protein molecules. Notably, many of the proteins used in industrial applications are involved in redox chemistry, and thus often contain metal ions or metal-associated cofactors. In this review article, we focus on the current understanding of protein structure-function relationship in the presence of ILs, specifically focusing on the effect of ILs on metal containing proteins.
AB - In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline. Therefore, there is a pressing need to understand the structure and function of proteins in novel environments with ILs. Understanding the short-term and long-term stability of protein molecules in IL formulations will be key to using ILs for protein technologies. Similarly, ILs have been investigated as part of therapeutic delivery systems and implicated in numerous studies in which ILs impact the activity and/or stability of protein molecules. Notably, many of the proteins used in industrial applications are involved in redox chemistry, and thus often contain metal ions or metal-associated cofactors. In this review article, we focus on the current understanding of protein structure-function relationship in the presence of ILs, specifically focusing on the effect of ILs on metal containing proteins.
UR - http://www.scopus.com/inward/record.url?scp=85100326194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100326194&partnerID=8YFLogxK
U2 - 10.3390/molecules26020514
DO - 10.3390/molecules26020514
M3 - Article
C2 - 33478102
AN - SCOPUS:85100326194
VL - 26
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 2
M1 - 514
ER -