Effect of nutritional status and 5-fluorouracil on protein synthesis in parenterally alimented LEW/Mai rats

T. P. Stein, W. C. Hargrove, E. E. Miller, H. W. Wallace, G. P. Buzby, J. L. Mullen

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5 Scopus citations

Abstract

LEW/Mai rats bearing transplantable adenocarcinomas were maintained parenterally for 4 days on 1) a regimen adequate in amino acids and glucose and 2) severely hypo caloric glucose. Rats from both groups were given 17.5 mg 5-fluorouracil (FUra)/kg/day as a continuous infusion for 3 days. Cumulative nitrogen balance, fractional tissue protein synthesis rates, and liver and muscle distribution of FUra and its metabolites were determined. Results were compared to those found with a series of control rats that were not treated with FUra. No changes attributable to FUra were found in the starved rats (1.25 g glucose/day). In the fed rats (15 g glucose plus 2.5 g amino acids/day), FUra decreased the liver and diaphragm fractional protein synthesis rates and the nitrogen retention.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalJournal of the National Cancer Institute
Volume63
Issue number2
DOIs
StatePublished - Aug 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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