EFFECT OF FISH OIL FEEDING ON BLOOD PRESSURE AND VASCULAR REACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS

K. Yin, Z. M. Chu, L. J. Beilin

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

1. To examine possible antihypertensive mechanisms of fish oil feeding, we have studied vascular reactivity of aortic rings and blood pressure of spontaneously hypertensive rats (SHR). 2. SHR were fed a synthetic diet supplemented with either (10% by weight) ‘Max EPA’ fish oil or hydrogenated coconut oil (saturated fat) for 4 weeks. 3. Mean systolic blood pressure of fish oil fed rats was 9 mmHg lower than saturated fat fed controls. 4. Aortic rings of control SHR had a biphasic response to acetylcholine (ACh), relaxing at lower concentrations but contracting at concentrations higher than 3X10‐7 mol/L. No such contractions were seen in tissues of fish oil fed rats. The contractions were abolished by indomethacin, suggesting that they were caused by a cyclo‐oxygenase product. 5. Tissue analysis showed that both aortic and serum generation of thromboxane B2 (TxB2) was approximately three times less in fish oil fed rats than in control tissues. 6. These results indicate that the lowering of blood pressure in fish oil fed SHR could in part be due to decrease in production of thromboxane (TxA2), a potent vasoconstrictor, hence influencing vascular tone and compliance of the aorta.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume17
Issue number3
DOIs
StatePublished - Mar 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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