Effect of 1-methyl-4-phemyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse

T. N. Ferraro, G. T. Golden, M. DeMattei, T. A. Hare, R. G. Fariello

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Treatment of mice with the proximate neurotoxin MPTP depletes striatal dopamine levels. Depletion of striatal dopamine and metabolites in MPTP-treated mice is accompanied by depletion of glutathione (GSH) in the substantia nigra (SN). Striatal GSH and nigral amino acid levels were not significantly affected by MPTP. Results suggest that GSH depletion in SN may represent an index of regional vulnerability to metabolic oxidative stress and also of selective susceptibility to the toxic effects of MPTP.

Original languageEnglish (US)
Pages (from-to)1071-1074
Number of pages4
JournalNeuropharmacology
Volume25
Issue number9
DOIs
StatePublished - Sep 1986

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

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