Effect of 1-methyl-4-phemyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse

T. N. Ferraro; G. T. Golden; M. DeMattei; T. A. Hare; R. G. Fariello

doi:10.1016/0028-3908(86)90205-4

Effect of 1-methyl-4-phemyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse

T. N. Ferraro, G. T. Golden, M. DeMattei, T. A. Hare, R. G. Fariello

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Treatment of mice with the proximate neurotoxin MPTP depletes striatal dopamine levels. Depletion of striatal dopamine and metabolites in MPTP-treated mice is accompanied by depletion of glutathione (GSH) in the substantia nigra (SN). Striatal GSH and nigral amino acid levels were not significantly affected by MPTP. Results suggest that GSH depletion in SN may represent an index of regional vulnerability to metabolic oxidative stress and also of selective susceptibility to the toxic effects of MPTP.

Original language	English (US)
Pages (from-to)	1071-1074
Number of pages	4
Journal	Neuropharmacology
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/0028-3908(86)90205-4
State	Published - Sep 1986
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Cellular and Molecular Neuroscience

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title = "Effect of 1-methyl-4-phemyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse",

abstract = "Treatment of mice with the proximate neurotoxin MPTP depletes striatal dopamine levels. Depletion of striatal dopamine and metabolites in MPTP-treated mice is accompanied by depletion of glutathione (GSH) in the substantia nigra (SN). Striatal GSH and nigral amino acid levels were not significantly affected by MPTP. Results suggest that GSH depletion in SN may represent an index of regional vulnerability to metabolic oxidative stress and also of selective susceptibility to the toxic effects of MPTP.",

author = "Ferraro, {T. N.} and Golden, {G. T.} and M. DeMattei and Hare, {T. A.} and Fariello, {R. G.}",

year = "1986",

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T1 - Effect of 1-methyl-4-phemyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse

AU - Ferraro, T. N.

AU - Golden, G. T.

AU - DeMattei, M.

AU - Hare, T. A.

AU - Fariello, R. G.

PY - 1986/9

Y1 - 1986/9

N2 - Treatment of mice with the proximate neurotoxin MPTP depletes striatal dopamine levels. Depletion of striatal dopamine and metabolites in MPTP-treated mice is accompanied by depletion of glutathione (GSH) in the substantia nigra (SN). Striatal GSH and nigral amino acid levels were not significantly affected by MPTP. Results suggest that GSH depletion in SN may represent an index of regional vulnerability to metabolic oxidative stress and also of selective susceptibility to the toxic effects of MPTP.

AB - Treatment of mice with the proximate neurotoxin MPTP depletes striatal dopamine levels. Depletion of striatal dopamine and metabolites in MPTP-treated mice is accompanied by depletion of glutathione (GSH) in the substantia nigra (SN). Striatal GSH and nigral amino acid levels were not significantly affected by MPTP. Results suggest that GSH depletion in SN may represent an index of regional vulnerability to metabolic oxidative stress and also of selective susceptibility to the toxic effects of MPTP.

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JO - Neuropharmacology

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ER -

Effect of 1-methyl-4-phemyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse

Abstract

All Science Journal Classification (ASJC) codes

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