Dynamic Nuclear Polarization of Selectively 29Si-Enriched Core@shell Silica Nanoparticles

Jiwon Kim, Incheol Heo, Quy Son Luu, Quynh Thi Nguyen, Uyen Thi Do, Nicholas Whiting, Seung Hyun Yang, Yong Min Huh, Sun Joon Min, Jeong Hyun Shim, Won Cheol Yoo, Youngbok Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

29Si silica nanoparticles (SiO2 NPs) are promising magnetic resonance imaging (MRI) probes that possess advantageous properties for in vivo applications, including suitable biocompatibility, tailorable properties, and high water dispersibility. Dynamic nuclear polarization (DNP) is used to enhance 29Si MR signals via enhanced nuclear spin alignment; to date, there has been limited success employing DNP for SiO2 NPs due to the lack of endogenous electronic defects that are required for the process. To create opportunities for SiO2-based 29Si MRI probes, we synthesized variously featured SiO2 NPs with selective 29Si isotope enrichment on homogeneous and core@shell structures (shell thickness: 10 nm, core size: 40 nm), and identified the critical factors for optimal DNP signal enhancement as well as the effective hyperpolarization depth when using an exogenous radical. Based on the synthetic design, this critical factor is the proportion of 29Si in the shell layer regardless of core enrichment. Furthermore, the effective depth of hyperpolarization is less than 10 nm between the surface and core, which demonstrates an approximately 40% elongated diffusion length for the shell-enriched NPs compared to the natural abundance NPs. This improved regulation of surface properties facilitates the development of isotopically enriched SiO2 NPs as hyperpolarized contrast agents for in vivo MRI.

Original languageEnglish (US)
Pages (from-to)907-916
Number of pages10
JournalAnalytical Chemistry
Volume95
Issue number2
DOIs
StatePublished - Jan 17 2023

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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