TY - JOUR
T1 - Drug release characteristics of unimolecular polymeric micelles
AU - Liu, Hongbo
AU - Farrell, Stephanie
AU - Uhrich, Kathryn
N1 - Funding Information:
The authors are grateful to Johnson & Johnson and Hoechst-Celanese for financial support. The technical assistance of Niraj Joshi of Rutgers University and efforts of Megan Matricardi and Kim Ha of Rowan University are also gratefully acknowledged.
PY - 2000/8/10
Y1 - 2000/8/10
N2 - Biodegradable, unimolecular polymeric micelles possess several features that are attractive for drug delivery applications: Thermodynamic stability, ability to encapsulate and solubilize a hydrophobic guest molecule, biodegradability, as well as size and surface characteristics that prevent rapid clearance by the RES. Here we investigate the potential of these unimolecular polymeric micelles to release a drug for an extended time. Lidocaine was used as a model drug for in vitro studies using a horizontal diffusion cell and cellulose membrane that prevented polymer transport from the source to the receiver compartment. The transport of free lidocaine from source to receiver under sink conditions was zero-order and complete within 8 h. The transport of lidocaine initially encapsulated in polymer was zero-order for the first 14 h, and 96% of the lidocaine was detected within 24 h. Copyright (C) 2000 Elsevier Science B.V.
AB - Biodegradable, unimolecular polymeric micelles possess several features that are attractive for drug delivery applications: Thermodynamic stability, ability to encapsulate and solubilize a hydrophobic guest molecule, biodegradability, as well as size and surface characteristics that prevent rapid clearance by the RES. Here we investigate the potential of these unimolecular polymeric micelles to release a drug for an extended time. Lidocaine was used as a model drug for in vitro studies using a horizontal diffusion cell and cellulose membrane that prevented polymer transport from the source to the receiver compartment. The transport of free lidocaine from source to receiver under sink conditions was zero-order and complete within 8 h. The transport of lidocaine initially encapsulated in polymer was zero-order for the first 14 h, and 96% of the lidocaine was detected within 24 h. Copyright (C) 2000 Elsevier Science B.V.
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U2 - 10.1016/S0168-3659(00)00247-9
DO - 10.1016/S0168-3659(00)00247-9
M3 - Article
C2 - 10925125
AN - SCOPUS:0034632952
SN - 0168-3659
VL - 68
SP - 167
EP - 174
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2
ER -