Drastic sensing enhancement using acoustic bubbles for surface-based microfluidic sensors

Andrea De Vellis, Dmitry Gritsenko, Yang Lin, Zhenping Wu, Xian Zhang, Yayue Pan, Wei Xue, Jie Xu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


There is a high demand for ultrafast biosensors for industrial and public health applications. However, the performance of existing sensors is often limited by the slow mass transport process in traditional pressure-driven microfluidic devices. In this paper, we show for the first time that acoustic microbubbles trapped in prefabricated cavities in a micro-chamber are capable of enhancing fluid sample mixing that results in faster delivery of target species to the sensor surface. We demonstrate a drastic reduction of sensor response time (up to 21.3-fold) for surface-based nanosensors in presence of resonantly actuated microbubbles. The obtained results are valid in a wide pH (4–10) range and agree well with previous studies.

Original languageEnglish (US)
Pages (from-to)298-302
Number of pages5
JournalSensors and Actuators, B: Chemical
StatePublished - May 1 2017

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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