DMA damage inhibition by dietary antioxidants: Voltammetric detection of inhibition using metallopolymer catalysts

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Abstract

Inhibition of deoxyribonucleic acid (DNA) damage by dietary antioxidant, vitamin C (ascorbic acid) using metallopolymer films is discussed. Metallopolymer films containing DNA and monitored DNA damage after incubation with reactive oxygen species (ROS) in the presence and absence of antioxidants are used. Fenton reagent was used to generate free radicals under standard conditions. The combination of ruthenium and osmium metallopolymers in the films provided a catalytic Os square wave voltammetry (SWV) peak that is mainly selective for 8-oxoguanine and the detection of other oxidized nucleobases from the Ru peak.

Original languageEnglish (US)
JournalElectrochemical Society Interface
Volume13
Issue number4
Publication statusPublished - Dec 1 2004

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All Science Journal Classification (ASJC) codes

  • Electrochemistry

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