Inhibition of deoxyribonucleic acid (DNA) damage by dietary antioxidant, vitamin C (ascorbic acid) using metallopolymer films is discussed. Metallopolymer films containing DNA and monitored DNA damage after incubation with reactive oxygen species (ROS) in the presence and absence of antioxidants are used. Fenton reagent was used to generate free radicals under standard conditions. The combination of ruthenium and osmium metallopolymers in the films provided a catalytic Os square wave voltammetry (SWV) peak that is mainly selective for 8-oxoguanine and the detection of other oxidized nucleobases from the Ru peak.
|Original language||English (US)|
|Journal||Electrochemical Society Interface|
|Publication status||Published - Dec 1 2004|
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