Abstract
Herein is reported the selective transformation of aldehydes to nitriles in the presence of hydroxylamine-O-sulfonic acid (NH2OSO3H) as a source of the N atom and acidic water. The reaction works with high yields for a large array of aromatic and aliphatic aldehydes, as well as hindered aldehydes and conjugated aldehydes without purification. The reaction conditions are very mild and tolerate a wide array of functional groups. In principle, the reaction can be completed in vinegar.
Original language | English (US) |
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Pages (from-to) | 3844-3847 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 57 |
Issue number | 34 |
DOIs | |
State | Published - 2016 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry