Direct Synthesis of Cyanopyrrolidinyl β-Amino Alcohols for the Development of Diabetes Therapeutics

Joseph R. Lizza, Savan V. Patel, Catherine F. Yang, Gustavo Moura-Letts

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Cyanopyrrolidinyl β-amino alcohols are novel scaffolds with potential for a wide array of pharmacological properties. We have discovered that we can selectively access these scaffolds from simple and inexpensive commercially available chemicals in few synthetic steps with minimal purification. We have produced a 36-compound library of these scaffolds and tested them as dipeptidyl peptidase IV (DPP4) inhibitors. These novel inhibitors are useful in the treatment of diabetes and inflammatory disorders.

Original languageEnglish (US)
Pages (from-to)5160-5168
Number of pages9
JournalEuropean Journal of Organic Chemistry
Volume2016
Issue number30
DOIs
StatePublished - Oct 2016

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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