Direct Synthesis of Cyanopyrrolidinyl β-Amino Alcohols for the Development of Diabetes Therapeutics

Joseph R. Lizza; Savan V. Patel; Catherine F. Yang; Gustavo Moura-Letts

doi:10.1002/ejoc.201600969

Direct Synthesis of Cyanopyrrolidinyl β-Amino Alcohols for the Development of Diabetes Therapeutics

Joseph R. Lizza, Savan V. Patel, Catherine F. Yang, Gustavo Moura-Letts

Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Cyanopyrrolidinyl β-amino alcohols are novel scaffolds with potential for a wide array of pharmacological properties. We have discovered that we can selectively access these scaffolds from simple and inexpensive commercially available chemicals in few synthetic steps with minimal purification. We have produced a 36-compound library of these scaffolds and tested them as dipeptidyl peptidase IV (DPP4) inhibitors. These novel inhibitors are useful in the treatment of diabetes and inflammatory disorders.

Original language	English (US)
Pages (from-to)	5160-5168
Number of pages	9
Journal	European Journal of Organic Chemistry
Volume	2016
Issue number	30
DOIs	https://doi.org/10.1002/ejoc.201600969
State	Published - Oct 2016

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Organic Chemistry

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10.1002/ejoc.201600969

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abstract = "Cyanopyrrolidinyl β-amino alcohols are novel scaffolds with potential for a wide array of pharmacological properties. We have discovered that we can selectively access these scaffolds from simple and inexpensive commercially available chemicals in few synthetic steps with minimal purification. We have produced a 36-compound library of these scaffolds and tested them as dipeptidyl peptidase IV (DPP4) inhibitors. These novel inhibitors are useful in the treatment of diabetes and inflammatory disorders.",

author = "Lizza, {Joseph R.} and Patel, {Savan V.} and Yang, {Catherine F.} and Gustavo Moura-Letts",

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year = "2016",

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AU - Patel, Savan V.

AU - Yang, Catherine F.

AU - Moura-Letts, Gustavo

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N2 - Cyanopyrrolidinyl β-amino alcohols are novel scaffolds with potential for a wide array of pharmacological properties. We have discovered that we can selectively access these scaffolds from simple and inexpensive commercially available chemicals in few synthetic steps with minimal purification. We have produced a 36-compound library of these scaffolds and tested them as dipeptidyl peptidase IV (DPP4) inhibitors. These novel inhibitors are useful in the treatment of diabetes and inflammatory disorders.

AB - Cyanopyrrolidinyl β-amino alcohols are novel scaffolds with potential for a wide array of pharmacological properties. We have discovered that we can selectively access these scaffolds from simple and inexpensive commercially available chemicals in few synthetic steps with minimal purification. We have produced a 36-compound library of these scaffolds and tested them as dipeptidyl peptidase IV (DPP4) inhibitors. These novel inhibitors are useful in the treatment of diabetes and inflammatory disorders.

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JF - European Journal of Organic Chemistry

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ER -

Direct Synthesis of Cyanopyrrolidinyl β-Amino Alcohols for the Development of Diabetes Therapeutics

Abstract

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