Differential modulatory effects of norepinephrine on synaptically driven responses of layer V barrel field cortical neurons

Barry D. Waterhouse, Robert Mouradian, Francis M. Sessler, Rick C.S. Lin

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The effects of norepinephrine (NE) and the alpha-1 agonist phenylephrine (PE) on synaptically evoked responses of electrophysiologically identified pyramidal neurons in layer V of rat somatosensory cortex were studied in brain slices using intracellular recording techniques. When added to the bathing medium NE (10 µM) tended to increase the synaptic responsiveness of regular spiking neurons and decrease the responsiveness of intrinsic burst neurons. NE had mixed effects on layer V cells which were characterized as intermediate types between regular spiking and intrinsic burst neurons. PE exerted a similar spectrum of actions on layer V cortical neurons. For both adrenergic agents the greatest facilitating effect was observed on responses to low intensity synaptic stimulation. These results suggest that NE exerts different modulatory actions on different electrophysiologically-defined classes of layer V sensory cortical neurons.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalBrain Research
Volume868
Issue number1
DOIs
StatePublished - Jun 16 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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