Dietary nutraceuticals as backbone for bone health

Manoj K. Pandey, Subash C. Gupta, Deepkamal Karelia, Patrick J. Gilhooley, Mehdi Shakibaei, Bharat B. Aggarwal

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Bone loss or osteoporosis, is a slow-progressing disease that results from dysregulation of pro-inflammatory cytokines. The FDA has approved number of drugs for bone loss prevention, nonetheless all are expensive and have multiple side effects. The nutraceuticals identified from dietary agents such as butein, cardamonin, coronarin D curcumin, diosgenin, embelin, gambogic acid, genistein, plumbagin, quercetin, reseveratrol, zerumbone and more, can modulate cell signaling pathways and reverse/slow down osteoporosis. Most of these nutraceuticals are inexpensive; show no side effect while still possessing anti-inflammatory properties. This review provides various mechanisms of osteoporosis and how nutraceuticals can potentially prevent the bone loss.

Original languageEnglish (US)
Pages (from-to)1633-1648
Number of pages16
JournalBiotechnology Advances
Issue number6
StatePublished - Nov 1 2018

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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