TY - JOUR
T1 - Dietary nutraceuticals as backbone for bone health
AU - Pandey, Manoj K.
AU - Gupta, Subash C.
AU - Karelia, Deepkamal
AU - Gilhooley, Patrick J.
AU - Shakibaei, Mehdi
AU - Aggarwal, Bharat B.
N1 - Publisher Copyright:
© 2018
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Bone loss or osteoporosis, is a slow-progressing disease that results from dysregulation of pro-inflammatory cytokines. The FDA has approved number of drugs for bone loss prevention, nonetheless all are expensive and have multiple side effects. The nutraceuticals identified from dietary agents such as butein, cardamonin, coronarin D curcumin, diosgenin, embelin, gambogic acid, genistein, plumbagin, quercetin, reseveratrol, zerumbone and more, can modulate cell signaling pathways and reverse/slow down osteoporosis. Most of these nutraceuticals are inexpensive; show no side effect while still possessing anti-inflammatory properties. This review provides various mechanisms of osteoporosis and how nutraceuticals can potentially prevent the bone loss.
AB - Bone loss or osteoporosis, is a slow-progressing disease that results from dysregulation of pro-inflammatory cytokines. The FDA has approved number of drugs for bone loss prevention, nonetheless all are expensive and have multiple side effects. The nutraceuticals identified from dietary agents such as butein, cardamonin, coronarin D curcumin, diosgenin, embelin, gambogic acid, genistein, plumbagin, quercetin, reseveratrol, zerumbone and more, can modulate cell signaling pathways and reverse/slow down osteoporosis. Most of these nutraceuticals are inexpensive; show no side effect while still possessing anti-inflammatory properties. This review provides various mechanisms of osteoporosis and how nutraceuticals can potentially prevent the bone loss.
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U2 - 10.1016/j.biotechadv.2018.03.014
DO - 10.1016/j.biotechadv.2018.03.014
M3 - Review article
C2 - 29597029
AN - SCOPUS:85045063574
SN - 0734-9750
VL - 36
SP - 1633
EP - 1648
JO - Biotechnology Advances
JF - Biotechnology Advances
IS - 6
ER -