Diazepam inhibits the spreading of chick embryo fibroblasts

R. G. Nagele, J. F. Pietrolungo, M. C. Kosciuk, H. Lee, F. J. Roisen

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Diazepam (Valium/Roche), a benzodiazepine derivative, reversibly inhibited the spreading of chick embryo fibroblasts in a dose-related manner. This inhibition was accompanied by: 1. 1 Fewer and less organized microfilament bundles. 2. 2 A reduction in myosin fluorescence along these structures. 3. 3 A reduction in the total myosin content of cells compared to corresponding controls. Overall results suggest that myosin plays an active role in the spreading of chick embryo fibroblasts.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
JournalExperimental Cell Research
Volume143
Issue number1
DOIs
StatePublished - Jan 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology

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