Diazepam inhibits neurulation through its action on myosin-containing microfilaments in early chick embryos

Hsi N.Yi Lee; Michael F. Keresztury; Mary C. Kosciuk; Robert G. Nagele; Fred J. Roisen

doi:10.1016/0742-8413(84)90023-9

Diazepam inhibits neurulation through its action on myosin-containing microfilaments in early chick embryos

Hsi N.Yi Lee, Michael F. Keresztury, Mary C. Kosciuk, Robert G. Nagele, Fred J. Roisen

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

1. 1. Diazepam (Valium/Roche) inhibited the morphogenesis of explanted stage 8 chick embryos in a dose-related manner. 2. 2. Diazepam, at concn of 400-500 Mg/ml, preferentially inhibited closure of the neural tube. This inhibition was accompanied by a significant reduction in myosin content of the developing neuroepithelium. 3. 3. Diazepam can be used as a probe to study the contributory role of myosin in cellular and morphogenetic movements.

Original language	English (US)
Pages (from-to)	331-334
Number of pages	4
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/0742-8413(84)90023-9
State	Published - 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology
Pharmacology

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10.1016/0742-8413(84)90023-9

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title = "Diazepam inhibits neurulation through its action on myosin-containing microfilaments in early chick embryos",

abstract = "1. 1. Diazepam (Valium/Roche) inhibited the morphogenesis of explanted stage 8 chick embryos in a dose-related manner. 2. 2. Diazepam, at concn of 400-500 Mg/ml, preferentially inhibited closure of the neural tube. This inhibition was accompanied by a significant reduction in myosin content of the developing neuroepithelium. 3. 3. Diazepam can be used as a probe to study the contributory role of myosin in cellular and morphogenetic movements.",

author = "Lee, {Hsi N.Yi} and Keresztury, {Michael F.} and Kosciuk, {Mary C.} and Nagele, {Robert G.} and Roisen, {Fred J.}",

note = "Funding Information: Acknowledgements-Thisstu dy was supported by grants from the Research Council, Busch Memorial Fund of Rutgers University (H.L.) and NIH (F.J.R.).",

year = "1984",

doi = "10.1016/0742-8413(84)90023-9",

language = "English (US)",

volume = "77",

pages = "331--334",

journal = "Comparative Biochemistry and Physiology. Part C, Comparative",

issn = "0306-4492",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Diazepam inhibits neurulation through its action on myosin-containing microfilaments in early chick embryos

AU - Lee, Hsi N.Yi

AU - Keresztury, Michael F.

AU - Kosciuk, Mary C.

AU - Nagele, Robert G.

AU - Roisen, Fred J.

N1 - Funding Information: Acknowledgements-Thisstu dy was supported by grants from the Research Council, Busch Memorial Fund of Rutgers University (H.L.) and NIH (F.J.R.).

PY - 1984

Y1 - 1984

N2 - 1. 1. Diazepam (Valium/Roche) inhibited the morphogenesis of explanted stage 8 chick embryos in a dose-related manner. 2. 2. Diazepam, at concn of 400-500 Mg/ml, preferentially inhibited closure of the neural tube. This inhibition was accompanied by a significant reduction in myosin content of the developing neuroepithelium. 3. 3. Diazepam can be used as a probe to study the contributory role of myosin in cellular and morphogenetic movements.

AB - 1. 1. Diazepam (Valium/Roche) inhibited the morphogenesis of explanted stage 8 chick embryos in a dose-related manner. 2. 2. Diazepam, at concn of 400-500 Mg/ml, preferentially inhibited closure of the neural tube. This inhibition was accompanied by a significant reduction in myosin content of the developing neuroepithelium. 3. 3. Diazepam can be used as a probe to study the contributory role of myosin in cellular and morphogenetic movements.

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U2 - 10.1016/0742-8413(84)90023-9

DO - 10.1016/0742-8413(84)90023-9

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AN - SCOPUS:0021243380

SN - 0306-4492

VL - 77

SP - 331

EP - 334

JO - Comparative Biochemistry and Physiology. Part C, Comparative

JF - Comparative Biochemistry and Physiology. Part C, Comparative

IS - 2

ER -

Diazepam inhibits neurulation through its action on myosin-containing microfilaments in early chick embryos

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