Diazepam inhibits neurulation through its action on myosin-containing microfilaments in early chick embryos

Hsi N.Yi Lee, Michael F. Keresztury, Mary C. Kosciuk, Robert G. Nagele, Fred J. Roisen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

1. 1. Diazepam (Valium/Roche) inhibited the morphogenesis of explanted stage 8 chick embryos in a dose-related manner. 2. 2. Diazepam, at concn of 400-500 Mg/ml, preferentially inhibited closure of the neural tube. This inhibition was accompanied by a significant reduction in myosin content of the developing neuroepithelium. 3. 3. Diazepam can be used as a probe to study the contributory role of myosin in cellular and morphogenetic movements.

Original languageEnglish (US)
Pages (from-to)331-334
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume77
Issue number2
DOIs
StatePublished - 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

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