Diastereoselective dihydroxylation of dihydropyranones and subsequent regioselective α-deoxygenation provides 1,3-trans-β-hydroxy-6- lactones stereoselectively. This protocol has been applied for the synthesis of C1-C8 and C15-C21 subunits of (+)-discodermolide.
|Original language||English (US)|
|Number of pages||11|
|Journal||Journal of Organic Chemistry|
|State||Published - Sep 17 2004|
All Science Journal Classification (ASJC) codes
- Organic Chemistry