Development and testing of an intravascular artificial lung

W. J. Federspiel, J. F. Golob, B. J. Frankowski, Thomas Merrill, K. Litwak, B. G. Hattler

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Intravenous oxygenation represents a potential support modality for patients with acute and other respiratory failures. Our group has been developing an intravenous oxygenator, the IMO, which uses a rapidly pulsating balloon to enhance gas exchange performance. The purpose of this study was to compare the gas exchange of our current IMO device to that reported for a previous intravascular oxygenator, the IVOX, which underwent human clinical testing. An ex-vivo mock vena cava flow loop was constructed which was equivalent to that used previously for testing of the IVOX. The flow loop was perfused directly from an anesthetized calf with inflow from the IVC and outflow to the right atrium. O2 and CO2 gas exchange were measured from 1 to 4 1/2 LPM blood flows and for balloon pulsation rates up to 180 bpm. The gas exchange levels of the IMO at maximal balloon pulsation, normalized for fiber surface area, were approximately 1.5 to 3 times that of the IVOX. A significant finding was that balloon pulsation in the IMO reduced some of the natural dependence of the gas transfer rate on blood flowrate. Thus, in clinical application the IMO may exhibit less gas transfer variability due to differences in cardiac output.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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