Determining oxygen exchange from gas-side analysis in artificial lungs

Thomas Merrill, B. G. Hattler, W. J. Federspiel

Research output: Contribution to journalConference article

Abstract

Blood flow rates and blood tension values are difficult to attain during an invivo test of an intravascular artificial lung. As a result, a gas-side oxygen measurement technique is needed This study will discuss two techniques used to make these gas-side measurements, the simple mass balance approach and the Haldane correction approach, and make suggestions on their usage. The simple oxygen mass balance approach involves measuring both oxygen flow and oxygen concentration of both the gas inlet and gas outlet to the artificial lung. On the other hand, the Haldane correction approach couples an addition mass balance of a tracer gas with the simple oxygen mass balance equations to eliminate the need for one of the oxygen gas flow measurements. Using the simple mass balance approach and single sample uncertainty analysis, the oxygen gas exchange error is quite large at ± 90%. Using the Haldane correction approach, assuming that there is no tracer gas mass transfer, the single sample error is reduced to ± 40% However, small amounts of tracer gas mass transfer can significantly diminish the accuracy of the Haldane correction approach; a tracer gas mass transfer rate equivalent to only 1.0% of the carbon dioxide transfer rate can increase the oxygen exchange error to ± 60%. Due to the inherent Haldane correction approach sensitivity to small amounts of tracer gas mass transfer, oxygen gas exchange analysis of artificial lungs should be done using blood-side analysis with ex-vivo testing.

Original languageEnglish (US)
Number of pages1
JournalASAIO Journal
Volume46
Issue number2
DOIs
StatePublished - Jan 1 2000
Externally publishedYes
Event46th Annual Conference and Exposition of ASAIO - New York, NY, USA
Duration: Jun 28 2000Jul 1 2000

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Gases
Oxygen
Lung
Mass transfer
Blood
Gas fuel measurement
Uncertainty analysis
Flow measurement
Carbon Dioxide
Flow of gases
Carbon dioxide
Uncertainty
Flow rate
Testing

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Merrill, Thomas ; Hattler, B. G. ; Federspiel, W. J. / Determining oxygen exchange from gas-side analysis in artificial lungs. In: ASAIO Journal. 2000 ; Vol. 46, No. 2.
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abstract = "Blood flow rates and blood tension values are difficult to attain during an invivo test of an intravascular artificial lung. As a result, a gas-side oxygen measurement technique is needed This study will discuss two techniques used to make these gas-side measurements, the simple mass balance approach and the Haldane correction approach, and make suggestions on their usage. The simple oxygen mass balance approach involves measuring both oxygen flow and oxygen concentration of both the gas inlet and gas outlet to the artificial lung. On the other hand, the Haldane correction approach couples an addition mass balance of a tracer gas with the simple oxygen mass balance equations to eliminate the need for one of the oxygen gas flow measurements. Using the simple mass balance approach and single sample uncertainty analysis, the oxygen gas exchange error is quite large at ± 90{\%}. Using the Haldane correction approach, assuming that there is no tracer gas mass transfer, the single sample error is reduced to ± 40{\%} However, small amounts of tracer gas mass transfer can significantly diminish the accuracy of the Haldane correction approach; a tracer gas mass transfer rate equivalent to only 1.0{\%} of the carbon dioxide transfer rate can increase the oxygen exchange error to ± 60{\%}. Due to the inherent Haldane correction approach sensitivity to small amounts of tracer gas mass transfer, oxygen gas exchange analysis of artificial lungs should be done using blood-side analysis with ex-vivo testing.",
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Determining oxygen exchange from gas-side analysis in artificial lungs. / Merrill, Thomas; Hattler, B. G.; Federspiel, W. J.

In: ASAIO Journal, Vol. 46, No. 2, 01.01.2000.

Research output: Contribution to journalConference article

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