Abstract
Blood flow rates and blood tension values are difficult to attain during an invivo test of an intravascular artificial lung. As a result, a gas-side oxygen measurement technique is needed This study will discuss two techniques used to make these gas-side measurements, the simple mass balance approach and the Haldane correction approach, and make suggestions on their usage. The simple oxygen mass balance approach involves measuring both oxygen flow and oxygen concentration of both the gas inlet and gas outlet to the artificial lung. On the other hand, the Haldane correction approach couples an addition mass balance of a tracer gas with the simple oxygen mass balance equations to eliminate the need for one of the oxygen gas flow measurements. Using the simple mass balance approach and single sample uncertainty analysis, the oxygen gas exchange error is quite large at ± 90%. Using the Haldane correction approach, assuming that there is no tracer gas mass transfer, the single sample error is reduced to ± 40% However, small amounts of tracer gas mass transfer can significantly diminish the accuracy of the Haldane correction approach; a tracer gas mass transfer rate equivalent to only 1.0% of the carbon dioxide transfer rate can increase the oxygen exchange error to ± 60%. Due to the inherent Haldane correction approach sensitivity to small amounts of tracer gas mass transfer, oxygen gas exchange analysis of artificial lungs should be done using blood-side analysis with ex-vivo testing.
| Original language | English (US) |
|---|---|
| Number of pages | 1 |
| Journal | ASAIO Journal |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2000 |
| Externally published | Yes |
| Event | 46th Annual Conference and Exposition of ASAIO - New York, NY, USA Duration: Jun 28 2000 → Jul 1 2000 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Bioengineering
- Biomaterials
- Biomedical Engineering
Cite this
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Determining oxygen exchange from gas-side analysis in artificial lungs. / Merrill, Thomas; Hattler, B. G.; Federspiel, W. J.
In: ASAIO Journal, Vol. 46, No. 2, 01.01.2000.Research output: Contribution to journal › Conference article
TY - JOUR
T1 - Determining oxygen exchange from gas-side analysis in artificial lungs
AU - Merrill, Thomas
AU - Hattler, B. G.
AU - Federspiel, W. J.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Blood flow rates and blood tension values are difficult to attain during an invivo test of an intravascular artificial lung. As a result, a gas-side oxygen measurement technique is needed This study will discuss two techniques used to make these gas-side measurements, the simple mass balance approach and the Haldane correction approach, and make suggestions on their usage. The simple oxygen mass balance approach involves measuring both oxygen flow and oxygen concentration of both the gas inlet and gas outlet to the artificial lung. On the other hand, the Haldane correction approach couples an addition mass balance of a tracer gas with the simple oxygen mass balance equations to eliminate the need for one of the oxygen gas flow measurements. Using the simple mass balance approach and single sample uncertainty analysis, the oxygen gas exchange error is quite large at ± 90%. Using the Haldane correction approach, assuming that there is no tracer gas mass transfer, the single sample error is reduced to ± 40% However, small amounts of tracer gas mass transfer can significantly diminish the accuracy of the Haldane correction approach; a tracer gas mass transfer rate equivalent to only 1.0% of the carbon dioxide transfer rate can increase the oxygen exchange error to ± 60%. Due to the inherent Haldane correction approach sensitivity to small amounts of tracer gas mass transfer, oxygen gas exchange analysis of artificial lungs should be done using blood-side analysis with ex-vivo testing.
AB - Blood flow rates and blood tension values are difficult to attain during an invivo test of an intravascular artificial lung. As a result, a gas-side oxygen measurement technique is needed This study will discuss two techniques used to make these gas-side measurements, the simple mass balance approach and the Haldane correction approach, and make suggestions on their usage. The simple oxygen mass balance approach involves measuring both oxygen flow and oxygen concentration of both the gas inlet and gas outlet to the artificial lung. On the other hand, the Haldane correction approach couples an addition mass balance of a tracer gas with the simple oxygen mass balance equations to eliminate the need for one of the oxygen gas flow measurements. Using the simple mass balance approach and single sample uncertainty analysis, the oxygen gas exchange error is quite large at ± 90%. Using the Haldane correction approach, assuming that there is no tracer gas mass transfer, the single sample error is reduced to ± 40% However, small amounts of tracer gas mass transfer can significantly diminish the accuracy of the Haldane correction approach; a tracer gas mass transfer rate equivalent to only 1.0% of the carbon dioxide transfer rate can increase the oxygen exchange error to ± 60%. Due to the inherent Haldane correction approach sensitivity to small amounts of tracer gas mass transfer, oxygen gas exchange analysis of artificial lungs should be done using blood-side analysis with ex-vivo testing.
UR - http://www.scopus.com/inward/record.url?scp=0034159518&partnerID=8YFLogxK
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U2 - 10.1097/00002480-200003000-00118
DO - 10.1097/00002480-200003000-00118
M3 - Conference article
AN - SCOPUS:0034159518
VL - 46
JO - ASAIO Journal
JF - ASAIO Journal
SN - 1058-2916
IS - 2
ER -