Determination of fluorocarbon in blood

T. P. Stein; Winston K. Robbins; Helene B. Brooks; Herbert W. Wallace

doi:10.1002/jbm.820090510

Determination of fluorocarbon in blood

T. P. Stein, Winston K. Robbins, Helene B. Brooks, Herbert W. Wallace

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Because fluorocarbons can dissolve relatively large quantities of oxygen and carbon dioxide, there is considerable interest in utilizing them to develop new methods of extracorporael circulation, artificial red blood cells, and liquid breathing techniques. A method for the assay of fluorocarbon in blood is presented. The fluorocarbon is extracted from the blood with toluene, and fluoride is released from the fluorocarbon in the toluene extract by reaction with sodium biphenyl. The inorganic fluoride is then extracted with aqueous sodium acetate, the pH of the extract is adjusted, and the activity of the fluoride ion is read with a fluoride‐specific ion electrode. The assay was effective for fluorocarbon concentrations in the range 1 to 30 ppm.

Original language	English (US)
Pages (from-to)	479-485
Number of pages	7
Journal	Journal of Biomedical Materials Research
Volume	9
Issue number	5
DOIs	https://doi.org/10.1002/jbm.820090510
State	Published - Sep 1975
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering

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10.1002/jbm.820090510

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title = "Determination of fluorocarbon in blood",

abstract = "Because fluorocarbons can dissolve relatively large quantities of oxygen and carbon dioxide, there is considerable interest in utilizing them to develop new methods of extracorporael circulation, artificial red blood cells, and liquid breathing techniques. A method for the assay of fluorocarbon in blood is presented. The fluorocarbon is extracted from the blood with toluene, and fluoride is released from the fluorocarbon in the toluene extract by reaction with sodium biphenyl. The inorganic fluoride is then extracted with aqueous sodium acetate, the pH of the extract is adjusted, and the activity of the fluoride ion is read with a fluoride‐specific ion electrode. The assay was effective for fluorocarbon concentrations in the range 1 to 30 ppm.",

author = "Stein, {T. P.} and Robbins, {Winston K.} and Brooks, {Helene B.} and Wallace, {Herbert W.}",

year = "1975",

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AU - Stein, T. P.

AU - Robbins, Winston K.

AU - Brooks, Helene B.

AU - Wallace, Herbert W.

PY - 1975/9

Y1 - 1975/9

N2 - Because fluorocarbons can dissolve relatively large quantities of oxygen and carbon dioxide, there is considerable interest in utilizing them to develop new methods of extracorporael circulation, artificial red blood cells, and liquid breathing techniques. A method for the assay of fluorocarbon in blood is presented. The fluorocarbon is extracted from the blood with toluene, and fluoride is released from the fluorocarbon in the toluene extract by reaction with sodium biphenyl. The inorganic fluoride is then extracted with aqueous sodium acetate, the pH of the extract is adjusted, and the activity of the fluoride ion is read with a fluoride‐specific ion electrode. The assay was effective for fluorocarbon concentrations in the range 1 to 30 ppm.

AB - Because fluorocarbons can dissolve relatively large quantities of oxygen and carbon dioxide, there is considerable interest in utilizing them to develop new methods of extracorporael circulation, artificial red blood cells, and liquid breathing techniques. A method for the assay of fluorocarbon in blood is presented. The fluorocarbon is extracted from the blood with toluene, and fluoride is released from the fluorocarbon in the toluene extract by reaction with sodium biphenyl. The inorganic fluoride is then extracted with aqueous sodium acetate, the pH of the extract is adjusted, and the activity of the fluoride ion is read with a fluoride‐specific ion electrode. The assay was effective for fluorocarbon concentrations in the range 1 to 30 ppm.

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JF - Journal of Biomedical Materials Research

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ER -

Determination of fluorocarbon in blood

Abstract

All Science Journal Classification (ASJC) codes

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