Detection of Several Novel γ‐Aminobutyric Acid‐Containing Compounds in Human CSF

Joanne M. Miller, Thomas N. Ferraro, Theodore A. Hare

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Abstract: γ‐Aminobutyric acid (GABA) concentrations in human CSF are known to increase significantly after hydrolysis; however, the source of this increase has been unknown. Using either ion‐exchange or reverse‐phase chromatography coupled with on‐line alkaline hydrolysis, we have shown 2‐pyrrolidinone, the lactam of GABA, to be present in insufficient quantity to account for this increase. Subsequent experiments involving fraction collection of column eluents followed by acid hydrolysis and rechromatography demonstrated the presence of several previously undetected GABA‐containing compounds.

Original languageEnglish (US)
Pages (from-to)769-773
Number of pages5
JournalJournal of Neurochemistry
Issue number3
StatePublished - Sep 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience


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