Denatured plasma and platelet function

H. W. Wallace, E. M. Liquori, Thomas Stein, H. Brooks

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Thrombocytopenia and platelet dysfunction are well known complications of extracorporeal circulation. The production of “denatured” protein is a common occurrence with extracorporeal circulation even in the absence of a blood-gas interface. We subjected platelet-poor plasma to vigorous bubbling with air and studied the effect of this “denatured” plasma on platelets from the same donor. Aggregation induced by ADP, epinephrine or collagen was measured. The bubbled plasma decreased the delay in the onset of aggregation observed with collagen and eliminated the biphasic aggregation response induced by epinephrine. These data indicate that “denatured” protein may affect platelet function and may play a role in the thrombocytopenia and altered platelet function associated with extracorporeal circulation.

Original languageEnglish (US)
Pages (from-to)450-454
Number of pages5
JournalTransactions - American Society for Artificial Internal Organs
Issue number1
StatePublished - Jan 1 1975
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • General Medicine


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