TY - JOUR
T1 - Delineation of the Individual Effects of Vitamin E Isoforms on Early Life Incident Wheezing
AU - Stone, Cosby A.
AU - Cook-Mills, Joan
AU - Gebretsadik, Tebeb
AU - Rosas-Salazar, Christian
AU - Turi, Kedir
AU - Brunwasser, Steven M.
AU - Connolly, Alexandra
AU - Russell, Patty
AU - Liu, Zhouwen
AU - Costello, Kaitlin
AU - Hartert, Tina V.
N1 - Funding Information:
Supported by the National Institutes of Health: NIH/NHLBI (T32 HL87738) and NIH/NIGMS (5T32 GM007569-41 [to C.S.]), NIH/NIAID (U19 AI 095227 [to T.H.]), NIH (K24 AI 077930 [to T.H.]). The project described was also supported by the National Center for Advancing Translational Sciences (CTSA award No. UL1TR000445). Its contents are solely the responsibility of the authors and do not necessarily represent official views of the National Center for Advancing Translational Sciences or the National Institutes of Health. The authors declare no conflicts of interest.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/3
Y1 - 2019/3
N2 - Objectives: To test the hypothesis that maternal plasma alpha-tocopherol levels are associated with protection from childhood wheeze and that this protection is modified by gamma-tocopherol. Study design: We conducted a prospective nested study in the Infant Susceptibility to Pulmonary Infections and Asthma Following Respiratory Syncytial Virus Exposure birth cohort of 652 children with postpartum maternal plasma vitamin E isoforms used as a surrogate for pregnancy concentrations. Our outcomes were wheezing and recurrent wheezing over a 2-year period, ascertained using validated questionnaires. We assessed the association of alpha- and gamma-tocopherol with wheezing outcomes using multivariable adjusted logistic regression, and tested for interaction between the isoforms with respect to the risk for wheezing outcomes. Results: Children with wheezing (n = 547, n = 167; 31%) and recurrent wheezing (n = 545, n = 55; 10.1%) over a 2-year period were born to mothers with significantly lower postpartum maternal plasma concentrations of alpha-tocopherol, P =.016 and P =.007, respectively. In analyses of IQR increases, alpha-tocopherol was associated with decreased risk of wheezing (aOR 0.70 [95% CI 0.53,0.92]) and recurrent wheezing (aOR 0.63 [95% CI 0.42,0.95]). For gamma-tocopherol, the aOR for wheezing was 0.79 (95% CI 0.56-1.10) and the aOR for recurrent wheezing was 0.56 (95% CI 0.33-0.94, with nonmonotonic association). The association of alpha-tocopherol with wheezing was modified by gamma-tocopherol (P interaction =.05). Conclusions: Increases in postpartum maternal plasma alpha-tocopherol isoform concentrations were associated with decreased likelihood of wheezing over a 2-year period. Gamma-tocopherol modified this association.
AB - Objectives: To test the hypothesis that maternal plasma alpha-tocopherol levels are associated with protection from childhood wheeze and that this protection is modified by gamma-tocopherol. Study design: We conducted a prospective nested study in the Infant Susceptibility to Pulmonary Infections and Asthma Following Respiratory Syncytial Virus Exposure birth cohort of 652 children with postpartum maternal plasma vitamin E isoforms used as a surrogate for pregnancy concentrations. Our outcomes were wheezing and recurrent wheezing over a 2-year period, ascertained using validated questionnaires. We assessed the association of alpha- and gamma-tocopherol with wheezing outcomes using multivariable adjusted logistic regression, and tested for interaction between the isoforms with respect to the risk for wheezing outcomes. Results: Children with wheezing (n = 547, n = 167; 31%) and recurrent wheezing (n = 545, n = 55; 10.1%) over a 2-year period were born to mothers with significantly lower postpartum maternal plasma concentrations of alpha-tocopherol, P =.016 and P =.007, respectively. In analyses of IQR increases, alpha-tocopherol was associated with decreased risk of wheezing (aOR 0.70 [95% CI 0.53,0.92]) and recurrent wheezing (aOR 0.63 [95% CI 0.42,0.95]). For gamma-tocopherol, the aOR for wheezing was 0.79 (95% CI 0.56-1.10) and the aOR for recurrent wheezing was 0.56 (95% CI 0.33-0.94, with nonmonotonic association). The association of alpha-tocopherol with wheezing was modified by gamma-tocopherol (P interaction =.05). Conclusions: Increases in postpartum maternal plasma alpha-tocopherol isoform concentrations were associated with decreased likelihood of wheezing over a 2-year period. Gamma-tocopherol modified this association.
UR - http://www.scopus.com/inward/record.url?scp=85057861652&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057861652&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2018.10.045
DO - 10.1016/j.jpeds.2018.10.045
M3 - Article
C2 - 30527752
AN - SCOPUS:85057861652
SN - 0022-3476
VL - 206
SP - 156-163.e3
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -