Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

Evan S. O'Brien; Nathaniel V. Nucci; Brian Fuglestad; Cecilia Tommos; A. Joshua Wand

doi:10.1074/jbc.M115.689406

Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

Evan S. O'Brien
, Nathaniel V. Nucci
, Brian Fuglestad
, Cecilia Tommos
, A. Joshua Wand

Physics

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.

Original language	English (US)
Pages (from-to)	30879-30887
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	290
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M115.689406
State	Published - Dec 25 2015

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M115.689406

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abstract = "Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.",

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AU - Tommos, Cecilia

AU - Wand, A. Joshua

PY - 2015/12/25

Y1 - 2015/12/25

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AB - Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.

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Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

Abstract

All Science Journal Classification (ASJC) codes

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