Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

Evan S. O'Brien, Nathaniel V. Nucci, Brian Fuglestad, Cecilia Tommos, A. Joshua Wand

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.

Original languageEnglish (US)
Pages (from-to)30879-30887
Number of pages9
JournalJournal of Biological Chemistry
Volume290
Issue number52
DOIs
StatePublished - Dec 25 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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