Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

Evan S. O'Brien, Nathaniel V. Nucci, Brian Fuglestad, Cecilia Tommos, A. Joshua Wand

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.

Original languageEnglish (US)
Pages (from-to)30879-30887
Number of pages9
JournalJournal of Biological Chemistry
Volume290
Issue number52
DOIs
StatePublished - Dec 25 2015

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Cardiolipins
Cytochromes c
Apoptosis
Protein Unfolding
Micelles
Encapsulation
Nuclear magnetic resonance
Membranes
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

O'Brien, Evan S. ; Nucci, Nathaniel V. ; Fuglestad, Brian ; Tommos, Cecilia ; Wand, A. Joshua. / Defining the apoptotic trigger : The interaction of cytochrome c and cardiolipin. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 52. pp. 30879-30887.
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Defining the apoptotic trigger : The interaction of cytochrome c and cardiolipin. / O'Brien, Evan S.; Nucci, Nathaniel V.; Fuglestad, Brian; Tommos, Cecilia; Wand, A. Joshua.

In: Journal of Biological Chemistry, Vol. 290, No. 52, 25.12.2015, p. 30879-30887.

Research output: Contribution to journalArticle

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