Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

Evan S. O'Brien; Nathaniel V. Nucci; Brian Fuglestad; Cecilia Tommos; A. Joshua Wand

doi:10.1074/jbc.M115.689406

Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

Evan S. O'Brien, Nathaniel V. Nucci, Brian Fuglestad, Cecilia Tommos, A. Joshua Wand

Physics

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.

Original language	English (US)
Pages (from-to)	30879-30887
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	290
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M115.689406
State	Published - Dec 25 2015

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M115.689406

Cite this

@article{b8edb3788f4d470e8d36dcc8cb122c87,

title = "Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin",

abstract = "Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.",

author = "O'Brien, {Evan S.} and Nucci, {Nathaniel V.} and Brian Fuglestad and Cecilia Tommos and Wand, {A. Joshua}",

year = "2015",

month = dec,

day = "25",

doi = "10.1074/jbc.M115.689406",

language = "English (US)",

volume = "290",

pages = "30879--30887",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "52",

}

TY - JOUR

T1 - Defining the apoptotic trigger

T2 - The interaction of cytochrome c and cardiolipin

AU - O'Brien, Evan S.

AU - Nucci, Nathaniel V.

AU - Fuglestad, Brian

AU - Tommos, Cecilia

AU - Wand, A. Joshua

PY - 2015/12/25

Y1 - 2015/12/25

N2 - Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.

AB - Background: Binding of mitochondrial cardiolipin to cytochrome c is thought to trigger apoptosis. Results: Reverse micelle encapsulation mimics the confinement of the inner mitochrondrial membrane allowing binding of cardiolipin to be followed by NMR at atomic resolution. Conclusion: Cardiolipin interacts with cytochrome c without causing protein unfolding. Significance: A new model for the role of cytochrome c in apoptosis is required.

UR - http://www.scopus.com/inward/record.url?scp=84951811327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951811327&partnerID=8YFLogxK

U2 - 10.1074/jbc.M115.689406

DO - 10.1074/jbc.M115.689406

M3 - Article

C2 - 26487716

AN - SCOPUS:84951811327

SN - 0021-9258

VL - 290

SP - 30879

EP - 30887

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 52

ER -

Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this