Corticotropin-releasing hormone: From endocrinology to psychobiology

Mark A. Smith; Milchel A. Kling; Harvey J. Whitfield; Harry A. Brandt; Mark A. Demitrack; Thomas D. Geracioti; George P. Chrousos; Philip W. Gold

doi:10.1159/000181089

Corticotropin-releasing hormone: From endocrinology to psychobiology

Mark A. Smith, Milchel A. Kling, Harvey J. Whitfield, Harry A. Brandt, Mark A. Demitrack, Thomas D. Geracioti, George P. Chrousos, Philip W. Gold

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Corticotropin-releasing hormone (CRH) is a brain neuropeptide which coordinates the endocrine, autonomic and behavioral responses to stress. We review the abnormal response to exogenous CRH in various psychiatric syndromes, including major depression and anorexia nervosa. We also contrast pituitary responses to CRH in patients with depression versus Cushing’s disease. We hypothesize that CRH may play a role in the pathogenesis of various psychiatric syndromes which are characterized during their course by the symptom of depression.

Original language	English (US)
Pages (from-to)	66-71
Number of pages	6
Journal	Hormone Research in Paediatrics
Volume	31
Issue number	1-2
DOIs	https://doi.org/10.1159/000181089
State	Published - 1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1159/000181089

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abstract = "Corticotropin-releasing hormone (CRH) is a brain neuropeptide which coordinates the endocrine, autonomic and behavioral responses to stress. We review the abnormal response to exogenous CRH in various psychiatric syndromes, including major depression and anorexia nervosa. We also contrast pituitary responses to CRH in patients with depression versus Cushing{\textquoteright}s disease. We hypothesize that CRH may play a role in the pathogenesis of various psychiatric syndromes which are characterized during their course by the symptom of depression.",

author = "Smith, {Mark A.} and Kling, {Milchel A.} and Whitfield, {Harvey J.} and Brandt, {Harry A.} and Demitrack, {Mark A.} and Geracioti, {Thomas D.} and Chrousos, {George P.} and Gold, {Philip W.}",

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AU - Smith, Mark A.

AU - Kling, Milchel A.

AU - Whitfield, Harvey J.

AU - Brandt, Harry A.

AU - Demitrack, Mark A.

AU - Geracioti, Thomas D.

AU - Chrousos, George P.

AU - Gold, Philip W.

PY - 1989

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Corticotropin-releasing hormone: From endocrinology to psychobiology

Abstract

All Science Journal Classification (ASJC) codes

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