TY - JOUR
T1 - Controlled drug release from contact lenses
T2 - A comprehensive review from 1965-present
AU - White, C. J.
AU - Tieppo, A.
AU - Byrne, M. E.
N1 - Funding Information:
This work was supported by a grant from the National Science Foundation (NSF-CBET-0730903, Grant G00003191) and the US Department of Education (GAANN grant P200A060184; CJW is a US Department of Education GAANN fellow). MEB and CJW have financial interest in this work and are listed on pending patents, both US and abroad.
PY - 2011
Y1 - 2011
N2 - This review covers the progress within the field of drug releasing contact lenses since 1965. It highlights the enormous potential of controlled release mechanisms and offers a comprehensive, comparative review of lenses, drugs, methods, drug loading, drug delivery rate, and release duration. Methods have included molecular imprinting as well various forms of mediated release via carriers, surfactants, inclusion complexes, and molecular barriers. Drug-soaked lens were the earliest releasing lenses, but they offer very little control over the release profile with low drug loading, are characterized by decaying, Fickian release rates, and typically reach completion in a very short amount of time. Molecular imprinting is consistently one of the most promising and versatile methods of enhanced drug loading and extended release with tailorable control over release rate when factors are balanced such as lens thickness, material, and release media and conditions.
AB - This review covers the progress within the field of drug releasing contact lenses since 1965. It highlights the enormous potential of controlled release mechanisms and offers a comprehensive, comparative review of lenses, drugs, methods, drug loading, drug delivery rate, and release duration. Methods have included molecular imprinting as well various forms of mediated release via carriers, surfactants, inclusion complexes, and molecular barriers. Drug-soaked lens were the earliest releasing lenses, but they offer very little control over the release profile with low drug loading, are characterized by decaying, Fickian release rates, and typically reach completion in a very short amount of time. Molecular imprinting is consistently one of the most promising and versatile methods of enhanced drug loading and extended release with tailorable control over release rate when factors are balanced such as lens thickness, material, and release media and conditions.
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U2 - 10.1016/S1773-2247(11)50062-0
DO - 10.1016/S1773-2247(11)50062-0
M3 - Review article
AN - SCOPUS:80055055927
SN - 1773-2247
VL - 21
SP - 369
EP - 384
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
IS - 5
ER -