Contact normalization or escape from the matrix

Gary Goldberg, Harini Krishnan

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Cancer is a complex process that involves interactions between numerous cell types. In many cases, tumor cell expansion is prevented by other cells in the microenvironment. The growth and morphology of genetically transformed cells can be normalized by junctional communication with surrounding nontransformed cells. Tumor cells need to overcome this process, called “contact normalization”, before they can realize their malignant and metastatic potential. Here, we describe some fundamental aspects that underlie contact normalization, and how this information can be used to develop innovative ways to detect and treat many forms of cancer.

Original languageEnglish (US)
Title of host publicationIntercellular Communication In Cancer
PublisherSpringer Netherlands
Pages297-342
Number of pages46
ISBN (Electronic)9789401773805
ISBN (Print)9789401773799
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Goldberg, G., & Krishnan, H. (2015). Contact normalization or escape from the matrix. In Intercellular Communication In Cancer (pp. 297-342). Springer Netherlands. https://doi.org/10.1007/978-94-017-7380-5_12