Connexins in growth control and cancer

Christian C. Naus, Gary Goldberg, Wun Chey Sin

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Gap junctions, and their constituent connexin proteins, have long been considered to play a role in the control of cell growth and carcinogenesis. The current review will attempt to summarize the evidence supporting the long-held view that gap-junction channels themselves play a preeminent role in controlling cell proliferation and preventing carcinogenesis through mechanisms of direct intercellular communication. In addition, it is timely to address emerging roles of connexin proteins in their own right, not directly in their channel-forming function, i.e., nonjunctional functions.

Original languageEnglish (US)
Title of host publicationGap Junctions in Development and Disease
PublisherSpringer Berlin Heidelberg
Pages253-273
Number of pages21
ISBN (Print)3540261567, 9783540261568
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Naus, C. C., Goldberg, G., & Sin, W. C. (2005). Connexins in growth control and cancer. In Gap Junctions in Development and Disease (pp. 253-273). Springer Berlin Heidelberg. https://doi.org/10.1007/3-540-28621-7_12