Conjugated therapeutic proteins as a treatment for bacteria which trigger cancer development

Mohamed Halawa, Precious M. Newman, Tope Aderibigbe, Valerie J. Carabetta

Research output: Contribution to journalReview articlepeer-review

Abstract

In recent years, an increasing amount of research has focused on the intricate and complex correlation between bacterial infections and the development of cancer. Some studies even identified specific bacterial species as potential culprits in the initiation of carcinogenesis, which generated a great deal of interest in the creation of innovative therapeutic strategies aimed at addressing both the infection and the subsequent risk of cancer. Among these strategies, there has been a recent emergence of the use of conjugated therapeutic proteins, which represent a highly promising avenue in the field of cancer therapeutics. These proteins offer a dual-targeting approach that seeks to effectively combat both the bacterial infection and the resulting malignancies that may arise because of such infections. This review delves into the landscape of conjugated therapeutic proteins that have been intricately designed with the purpose of specifically targeting bacteria that have been implicated in the induction of cancer.

Original languageEnglish (US)
Article number111029
JournaliScience
Volume27
Issue number10
DOIs
StatePublished - Oct 18 2024

All Science Journal Classification (ASJC) codes

  • General

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