Conformational effects in sugar ions: Spectroscopic investigations in the gas phase and in solution

Ram Sagar, Svemir Rudić, David P. Gamblin, Eoin M. Scanlan, Timothy D. Vaden, Barbara Odell, Timothy D.W. Claridge, John P. Simons, Benjamin G. Davis

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    We present direct investigations of the conformational preferences of sugars with a positively charged substituent at their anomeric centre, C-1, which display in solution, a preference for an equatorial conformation - an apparent reversal of the normal anomeric effect. The investigations focus on the protonated monosaccharide, d-xylopyranosyl imidazolium in its α and β forms, first probed in a range of different solvents through NMR measurements and then in the gas phase, free of solvent or counterion interactions, through infrared multiphoton dissociation spectroscopy. The results, when compared and discussed in the light of density functional theory, ab initio and natural bond orbital calculations, expose the possible origins of the reversed conformational preference and provide a better understanding of the factors controlling conformational choice.

    Original languageEnglish (US)
    Pages (from-to)2307-2313
    Number of pages7
    JournalChemical Science
    Volume3
    Issue number7
    DOIs
    StatePublished - Jul 2012

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)

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