Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

Srinivas Tekkam; Joseph L. Johnson; Subash C. Jonnalagadda; Venkatram R. Mereddy

doi:10.1002/jhet.1578

Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

Srinivas Tekkam
, Joseph L. Johnson
, Subash C. Jonnalagadda
, Venkatram R. Mereddy

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.

Original language	English (US)
Pages (from-to)	955-958
Number of pages	4
Journal	Journal of Heterocyclic Chemistry
Volume	50
Issue number	4
DOIs	https://doi.org/10.1002/jhet.1578
State	Published - Jul 2013

All Science Journal Classification (ASJC) codes

Organic Chemistry

Access to Document

10.1002/jhet.1578

Cite this

@article{b4f2e96e17a941d38fb2cef702065ed8,

title = "Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams",

abstract = "A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.",

author = "Srinivas Tekkam and Johnson, \{Joseph L.\} and Jonnalagadda, \{Subash C.\} and Mereddy, \{Venkatram R.\}",

year = "2013",

month = jul,

doi = "10.1002/jhet.1578",

language = "English (US)",

volume = "50",

pages = "955--958",

journal = "Journal of Heterocyclic Chemistry",

issn = "0022-152X",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

AU - Tekkam, Srinivas

AU - Johnson, Joseph L.

AU - Jonnalagadda, Subash C.

AU - Mereddy, Venkatram R.

PY - 2013/7

Y1 - 2013/7

N2 - A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.

AB - A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.

UR - https://www.scopus.com/pages/publications/84880945085

UR - https://www.scopus.com/pages/publications/84880945085#tab=citedBy

U2 - 10.1002/jhet.1578

DO - 10.1002/jhet.1578

M3 - Article

AN - SCOPUS:84880945085

SN - 0022-152X

VL - 50

SP - 955

EP - 958

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 4

ER -

Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this