Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

Srinivas Tekkam; Joseph L. Johnson; Subash C. Jonnalagadda; Venkatram R. Mereddy

doi:10.1002/jhet.1578

Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

Srinivas Tekkam, Joseph L. Johnson, Subash C. Jonnalagadda, Venkatram R. Mereddy

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.

Original language	English (US)
Pages (from-to)	955-958
Number of pages	4
Journal	Journal of Heterocyclic Chemistry
Volume	50
Issue number	4
DOIs	https://doi.org/10.1002/jhet.1578
State	Published - Jul 2013

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1002/jhet.1578

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abstract = "A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.",

author = "Srinivas Tekkam and Johnson, {Joseph L.} and Jonnalagadda, {Subash C.} and Mereddy, {Venkatram R.}",

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AU - Jonnalagadda, Subash C.

AU - Mereddy, Venkatram R.

PY - 2013/7

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AB - A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.

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Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

Abstract

All Science Journal Classification (ASJC) codes

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