TY - JOUR
T1 - Concentration of caveolin-3 at the neuromuscular junction in young and old rat skeletal muscle fibers
AU - Carlson, Bruce M.
AU - Carlson, Jean A.
AU - Dedkov, Eduard I.
AU - McLennan, Ian S.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Caveolin-3, a muscle-specific member of the caveolin family, is strongly localized to the neuromuscular junction (NMJ) in adult rat muscle fibers, where it co-localizes with α-bungarotoxin staining. In 24-month-old rats, less distinct staining corresponds with the normal aging changes in the NMJ. After denervation, the pattern and intensity of staining begin to break up as early as 3 days, and by 10 days little staining remains. The functional implications of this concentration of caveolin-3 at the NMJ remain obscure, but it is possible that its absence could account for some of the phenotypic characteristics of individuals with caveolin-3 mutations.
AB - Caveolin-3, a muscle-specific member of the caveolin family, is strongly localized to the neuromuscular junction (NMJ) in adult rat muscle fibers, where it co-localizes with α-bungarotoxin staining. In 24-month-old rats, less distinct staining corresponds with the normal aging changes in the NMJ. After denervation, the pattern and intensity of staining begin to break up as early as 3 days, and by 10 days little staining remains. The functional implications of this concentration of caveolin-3 at the NMJ remain obscure, but it is possible that its absence could account for some of the phenotypic characteristics of individuals with caveolin-3 mutations.
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U2 - 10.1177/002215540305100901
DO - 10.1177/002215540305100901
M3 - Article
C2 - 12923236
AN - SCOPUS:0042320696
SN - 0022-1554
VL - 51
SP - 1113
EP - 1118
JO - Journal of Histochemistry and Cytochemistry
JF - Journal of Histochemistry and Cytochemistry
IS - 9
ER -