Comprehensive in vitro studies of novel sol gel-derived Zr4+/Zn2+ co-substituted bioactive glass with enhanced biological properties for bone healing

Amirhossein Moghanian, Mohammadamin Zohourfazeli, Mahzad Haji Mahdi Tajer, Amir K. Miri

Research output: Contribution to journalArticlepeer-review

Abstract

The synergetic osteogenic effects of zirconium (Zr) and zinc (Zn) along with bioactive glasses (BGs) have been proposed for bone implantation. We incorporated Zn into Zr-modified 58S-BG (Zr content: 5 mol. %) and characterized the structural, morphological, biological, and antibacterial properties of the proposed composite using various methods. Energy-dispersive X-ray spectroscopy analysis showed the calcium to phosphate ratio of ~1.68, after one week of conditioning in SBF. Biological assays also revealed a higher stimulating effect of the biomaterial composite on the proliferation and osteogenic response of osteoblast-like cells compared to only BGs. Antibacterial studies showed ~ 5-10% reduction in resistivity of methicillin-resistant Staphylococcus Aureus (MRSA) bacteria against the biomaterial composite in comparison to the control specimen. The incorporation of Zn led to potential outlooks for implantations instead of Zn-free specimens since they promoted the cell proliferation of MC3T3 cells as well as resistivity toward MRSA bacteria.

Original languageEnglish (US)
Article number120887
JournalJournal of Non-Crystalline Solids
Volume566
DOIs
StatePublished - Aug 15 2021

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Condensed Matter Physics
  • Materials Chemistry

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