TY - GEN
T1 - Complexation hydrogels for stabilization of peptidic HIV-1 virucides
AU - Kubinski, P. L.
AU - Lowman, A. M.
AU - Kubinski, P. L.
AU - Duffy, C.
AU - Kantharaju,
AU - Contarino, M. R.
AU - Chaiken, I.
PY - 2012
Y1 - 2012
N2 - Human immunodeficiency virus 1 (HIV-1), the causative agent of acquired immune deficiency syndrome (AIDS), is a critical health priority. Although many therapies have been developed to slow the progression of AIDS, there are still no treatments available that can prevent or completely remove the infection. Recently, a highly potent, peptide triazole (PT) class of HIV-1 entry inhibitors has been identified that holds great promise for preventing HIV transmission. The purpose of this work is to enhance the in vivo stability of peptide triazoles by encapsulation in a pH-responsive hydrogel, composed of poly(methacrylic acid-g-ethylene glycol). Hydrogel loading and release of PT compositions are studied, and the stability of encapsulated PTs in enzymatic solutions is investigated.
AB - Human immunodeficiency virus 1 (HIV-1), the causative agent of acquired immune deficiency syndrome (AIDS), is a critical health priority. Although many therapies have been developed to slow the progression of AIDS, there are still no treatments available that can prevent or completely remove the infection. Recently, a highly potent, peptide triazole (PT) class of HIV-1 entry inhibitors has been identified that holds great promise for preventing HIV transmission. The purpose of this work is to enhance the in vivo stability of peptide triazoles by encapsulation in a pH-responsive hydrogel, composed of poly(methacrylic acid-g-ethylene glycol). Hydrogel loading and release of PT compositions are studied, and the stability of encapsulated PTs in enzymatic solutions is investigated.
UR - http://www.scopus.com/inward/record.url?scp=84862745126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862745126&partnerID=8YFLogxK
U2 - 10.1109/NEBC.2012.6206921
DO - 10.1109/NEBC.2012.6206921
M3 - Conference contribution
AN - SCOPUS:84862745126
SN - 9781467311410
T3 - 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
SP - 422
EP - 423
BT - 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
T2 - 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Y2 - 16 March 2012 through 18 March 2012
ER -